2021
DOI: 10.1186/s12879-021-06456-2
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SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

Abstract: Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered f… Show more

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Cited by 21 publications
(16 citation statements)
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“…Coinfection has been reported across tropical and subtropical dengue-endemic areas of the world. 5 Detailed clinical features and demographic representation in coinfected patients are described in Table 1 . Fever was the most consistent symptom in coinfected patients, although high grade fever was predominantly observed in dengue compared with COVID-19 patients.…”
Section: Resultsmentioning
confidence: 99%
“…Coinfection has been reported across tropical and subtropical dengue-endemic areas of the world. 5 Detailed clinical features and demographic representation in coinfected patients are described in Table 1 . Fever was the most consistent symptom in coinfected patients, although high grade fever was predominantly observed in dengue compared with COVID-19 patients.…”
Section: Resultsmentioning
confidence: 99%
“…Other COVID19 co-infections have been documented, for instance, the co-infection of Dengue virus and COVID19 has been reported 41 . Dengue and Chikinguniya -which are two zoonotic arboviral diseases -are endemic in Sudan, as well as malaria 42,43 .Tropical and subtropical countries experience high levels of infection with Dengue virus and Chikungunya virus during the monsoon season, and co-occurrence has been documented 44 .Malaria and dengue virus co-infection, as well as Malaria and Chikungunya virus co-infection have been reported in Sudan 43,45 .A co-infection with any or all of Malaria, Dengue virus, and Chikungunya virus; with COVID19 is predicted during the rainy season due to favorable breeding conditions for the mosquitoes, at the same time as the COVID19 pandemic could have a signi cant impact on public health 46 .…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, such antigenic similarity and cross-reactivity of immune responses of DENV and SARS-CoV-2 raise new diagnostic challenges in DENV-endemic regions in this time of COVID-19 pandemics [37,41,[44][45][46]. Indeed, the impact of antibody cross-reactivity and/or of co-infection with DENV and SARS-CoV-2 on misdiagnosis but also on the immune response of patients and consequently on the outcome of immunoassays, remains unexplored.…”
Section: Discussionmentioning
confidence: 99%