SARS-CoV-2 genomic surveillance in Northeast Brazil: timing of emergence of the Brazilian variant of concern P1

Santos, Cliomar Alves dos; Bezerra, Gabriela Vasconcelos Brito; Marinho, Aline Rafaelle Rocha Almeida de Azevedo; Alves, Juliana Cardoso; Tanajura, Diego Moura; Martins-Filho, Paulo Ricardo

doi:10.1093/jtm/taab066

Cited by 20 publications

(18 citation statements)

References 8 publications

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“…Similarly, other studies have reported cases of reinfection in essential service workers such as health professionals [19,20]. It is also worth highlighting the occurrence of the Brazilian variant P1 in the period of development of this study, further reinforcing the possibility of reinvention by SARS-CoV-2 [21].…”

Section: Discussionsupporting

confidence: 74%

Estimated SARS-CoV-2 Infection and Seroprevalence in Firefighters from a Northeastern Brazilian State: A Cross-Sectional Study

Borges

Nascimento

Heimfarth

et al. 2021

IJERPH

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The new coronavirus has been affecting health worldwide and essential service workers are continually exposed to this infectious agent, increasing the chance of infection and the development of the disease. Thus, this study aimed to estimate the frequency of infection and seroprevalence for SARS-CoV-2 in military firefighters in a city in Northeastern Brazil in January 2021. An observational cross-sectional study was carried out with 123 firefighters who answered a brief questionnaire to collect socio-epidemiological data and underwent RT-PCR and immunofluorescence test (IgM and IgG). The results found reveal a positive seroprevalence, with a high rate of infection in this class of workers, since they are essential service professionals who are exposed to risk due to their working hours, in addition to sharing some spaces and work materials. Besides, there were significant associations between positivity for IgG and IgM, as well as for positive RT-PCR prior to the study and the presence of IgG, with odd ratios of 3.04 and 4.9, respectively. These findings reinforce the need for immunization in this category, whose line of service hinders the adoption of distancing measures, since in many situations physical contact is inevitable.

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Section: Discussionsupporting

confidence: 74%

Estimated SARS-CoV-2 Infection and Seroprevalence in Firefighters from a Northeastern Brazilian State: A Cross-Sectional Study

Borges

Nascimento

Heimfarth

et al. 2021

IJERPH

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“…On the other hand, genomes originating in Brazil formed an isolated clade, probably for two reasons, such as the isolation that the other countries of the globe imposed on their air traffic with Brazil as well as the emergence of local variants such as P1 that quickly became the majority in the territory among Brazilian population, as can be seen from recently published epidemiological studies on this viral strain (Dos Santos et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF

Santos¹,

Carelli²,

Veras³

et al. 2021

Braz. J. Hea. Rev.

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Members of the Coronaviridae family comprise four genera Alphacoronavirus and Betacoronavirus, which infect only mammals, and Gammacoronavirus and Deltacoronavirus infect birds and mammals. Since the end of 2019, humanity has witnessed the emergence of a new pandemic caused by a line of beta-coronavirus (SARS-CoV-2) responsible for causing a novel severe acute respiratory syndrome named coronavirus disease (COVID-19) affecting countries worldwide. In this context, this work aimed to investigate the main changes in SARS-CoV-2 genomic architecture through the time since the beginning of the infection using in silico analysis. A genomic database was built using complete and revised genomes from NCBI as well as analyzed through sequencing alignment and phylogenetic softwares. This study was able to show a change in the organizational pattern of the genome of the new coronavirus for the different regions studied, in addition to showing specific changes in the genomic sequence requiring further analysis of the collected genomes and may provide new evidence for the key protein changes like Spike protein.

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“…The Gamma or P1 variant, also known as the Brazilian variant, was first reported in November 2020 in Brazil [52]. According to research, the Gamma variant is derived from B.1.1.28 [53]. Studies on the Gamma variant have shown that this species is 1.7-2.4 times more frequent than other species in Brazil.…”

Section: Sars-cov-2 Gamma Variant (Lineage P1)mentioning

confidence: 99%

SARS-CoV-2: phenotype, genotype, and characterization of different variants

et al. 2022

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), a major international public health concern. Because of very similar amino acid sequences of the seven domain names, SARS-CoV-2 belongs to the Coronavirinae subfamily of the family Coronaviridae, order Nidovirales, and realm Riboviria, placed in exceptional clusters, but categorized as a SARS-like species. As the RNA virus family with the longest genome, the Coronaviridae genome consists of a single strand of positive RNA (25–32 kb in length). Four major structural proteins of this genome include the spike (S), membrane (M), envelope (E), and the nucleocapsid (N) protein, all of which are encoded within the 3′ end of the genome. By engaging with its receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 infects host cells. According to the most recent epidemiological data, as the illness spread globally, several genetic variations of SARS-CoV-2 appeared quickly, with the World Health Organization (WHO) naming 11 of them. Among these, seven SARS-CoV-2 subtypes have received the most attention. Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.617.2) are now designated as variations of concern (VOC) (B.1.1.529). Lambda (C.37) and Mu are variations of interest (VOI) (B.1.621). The remaining six are either being monitored or are no longer considered a threat. On the basis of studies done so far, antiviral drugs, antibiotics, glucocorticoids, recombinant intravenous immunoglobulin, plasma therapy, and IFN-α2b have been used to treat patients. Moreover, full vaccination is associated with lower infection and helps prevent transmission, but the risk of infection cannot be eliminated completely in vaccinated people.

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SARS-CoV-2 genomic surveillance in Northeast Brazil: timing of emergence of the Brazilian variant of concern P1

Cited by 20 publications

References 8 publications

Estimated SARS-CoV-2 Infection and Seroprevalence in Firefighters from a Northeastern Brazilian State: A Cross-Sectional Study

Estimated SARS-CoV-2 Infection and Seroprevalence in Firefighters from a Northeastern Brazilian State: A Cross-Sectional Study

Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF

SARS-CoV-2: phenotype, genotype, and characterization of different variants

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