SARS-CoV-2 IgG seroprevalence in blood donors located in three different federal states, Germany, March to June 2020

Fischer, Bastian; Knabbe, Cornelius; Vollmer, Tanja

doi:10.2807/1560-7917.es.2020.25.28.2001285

Cited by 90 publications

(101 citation statements)

References 18 publications

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“…In other places where community transmission has been documented, they were accompanied by staggering morbidity and mortality rates; this however was not the case in the African continent. 25 The youthfulness of the African population, which has been identified as one of the protective factors against the disease severity, also comes to bear in this study because more than half of participants who were seropositive were between the age of 31-40 years. A review of the distribution of seropositivity within different cadres of healthcare workers suggested that the professionals who have more contact or spend more time with patients are more likely to be seropositive; this pattern has previously been described.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria

Olayanju

Bamidele

Edem

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Global health has been thrown into turmoil by the COVID-19 pandemic, which has caused devastating morbidity and unprecedented loss of life in almost all continents of the world. It was predicted that the magnitude of the pandemic in Africa will be high because of poor health structure and intensely poor living condition, but that has not happened, surprisingly. It was hypothesized that the youthful population and a vastly primed immune system were protective, and many people may have been exposed without coming down with the severe disease. Most of them would have presented in hospitals with other medical conditions and possibly transmit COVID-19 to health workers inadvertently. This study is designed to measure serum SARS-CoV-2 IgG levels in health workers as a marker of latent exposure. Asymptomatic frontline health workers were randomly selected from the University College Hospital Ibadan, Nigeria; venous blood samples were obtained from them, and the serum SARS-CoV-2 IgG level was determined using ELISA techniques. A proportion of participants with seropositivity were obtained, and factors associated with seropositivity were determined. A total of 133 participants were recruited for this study, and 60 (45.1%) of them were seropositive for SARS-CoV-2. Among the seropositive participants were doctors, nurses, health assistants, laboratory scientists and technicians, and nonmedical staff. Obstetrics, gynecology, and emergency departments had higher odds of seropositivity. Seroprevalence of SARS-CoV-2 is very high among frontline health workers, though asymptomatic. This calls for a more stringent precaution against further spread within the hospital environment.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria

Olayanju

Bamidele

Edem

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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“…Germany [87] This study assessed residue sera from 3186 regular blood donors collected during March 9-June 3 and obtained 29 positive results (raw prevalence 0•9%). The authors stated: "It should be emphasized that the preselection of blood donors as a study cohort is accompanied by limitations regarding representation of population.…”

Section: H2: Studies Excluded Due To Accelerating Outbreakmentioning

confidence: 99%

Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-analysis, & Public Policy Implications

Levin¹,

Hanage²,

Owusu‐Boaitey³

et al. 2020

105

129

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To assess age-specific infection fatality rates (IFRs) for COVID-19, we have conducted a systematic review of seroprevalence studies as well as countries with comprehensive tracing programs. Age-specific IFRs were computed using the prevalence data in conjunction with reported fatalities four weeks after the midpoint date of each study, reflecting typical lags in fatalities and reporting. Using metaregression procedures, we find a highly significant log-linear relationship between age and IFR for COVID-19. The estimated age-specific IFRs are very low for children and younger adults but increase progressively to 0.4% at age 55, 1.3% at age 65, 4.2% at age 75, and 14% at age 85. About 90% of the geographical variation in population IFR is explained by differences in age composition of the population and age-specific prevalence. These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults. Moreover, the population IFR for COVID-19 should not be viewed as a fixed parameter but as intrinsically linked to the age-specific pattern of infections. Consequently, public health measures to protect vulnerable age groups could substantially decrease total deaths.

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“…Similarly, in two independent seroprevalence studies performed in Barcelona province, also a nearly twofold higher risk was described for HCWs, ranging between 9.3% 12 and 10.3% 13 compared with 7% in the general province population 11 . Also in Germany, a population-based seroprevalence study denoted a 0.94% of IgG seroprevalence in the North Rhine-Westphalia region 23 , while a 1.6% was reported among healthcare workers of the University Hospital Essen located in the same region 18 .…”

Section: Discussionmentioning

confidence: 99%

IgG seroprevalence against SARS-CoV-2 in a cohort of 449 non-hospitalized, high-risk exposure individuals.

Martínez¹,

García²,

Salas³

et al. 2020

Preprint

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COVID-19 pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection. Mobility restrictions but also the requirement of a medical prescription to gain access to serological testing for COVID-19 were included among the measures. Under this scenario, between April 15th to June 15th, 2020, we performed a seroprevalence observational study including 449 individuals that fulfill prescription requirements: manifesting COVID-19 compatible symptoms, being in contact with a COVID-19 confirmed case or belonging to essential occupations including healthcare workers, firefighters or public safety personnel such as police. Importantly, none of the participants was hospitalized. Altogether, we studied this specific, non-commonly addressed cohort for SARS-CoV-2 seroprevalence, uncovering intrinsic features of great demographic interest. The overall rate of IgG seropositivity was 33.69% (95% CI: 29.27 – 38.21). This seroprevalence was comparable between different occupations performed by the participants. However, contacts with confirmed cases associated positively with IgG+ results, with stronger correlation if being a household member. The number of symptoms also correlated positively with IgG+ prevalence. Ageusia/anosmia, pneumonia and cutaneous manifestations were the top-three symptoms that most strongly associated with IgG+ seroprevalence. However, while pneumonia and cutaneous manifestations were barely present in our cohort, fever, ageusia/anosmia and asthenia were the most frequently symptoms described within IgG+ subjects. Therefore, our data illustrate how specific cohorts display heterogeneous characteristics that should be taken into account when identifying population seroprevalence against SARS-CoV-2 and key defining symptoms for COVID-19.

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SARS-CoV-2 IgG seroprevalence in blood donors located in three different federal states, Germany, March to June 2020

Cited by 90 publications

References 18 publications

SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria

SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria

Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-analysis, & Public Policy Implications

IgG seroprevalence against SARS-CoV-2 in a cohort of 449 non-hospitalized, high-risk exposure individuals.

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