2023
DOI: 10.1002/jnr.25171
|View full text |Cite
|
Sign up to set email alerts
|

SARS‐COV‐2 infection and Parkinson's disease: Possible links and perspectives

Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disease, with the most common form encompassing 95%-97% of all PD cases known as sporadic PD. Clinically PD is manifested by motor symptoms mainly consisting of bradykinesia, rest tremors, rigidity, and a range of non-motor features, such as constipation, depression, and disturbed sleep, which appear even 20 years before the onset of motor parkinsonism (Bloem et al., 2021). Neurodegeneration occurs in various brain regions, although specifically, dopa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
19
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 27 publications
(19 citation statements)
references
References 250 publications
(281 reference statements)
0
19
0
Order By: Relevance
“…The interaction of α-synuclein with SARS-CoV-2 is rather complex [ 64 ]. On the one hand, α-synuclein overexpression restricts SARS-CoV-2 neuroinvasion and reduces the degeneration of dopaminergic neurons.…”
Section: Antimicrobial and Antiviral Properties Of Amyloidogenic Ppsmentioning
confidence: 99%
See 1 more Smart Citation
“…The interaction of α-synuclein with SARS-CoV-2 is rather complex [ 64 ]. On the one hand, α-synuclein overexpression restricts SARS-CoV-2 neuroinvasion and reduces the degeneration of dopaminergic neurons.…”
Section: Antimicrobial and Antiviral Properties Of Amyloidogenic Ppsmentioning
confidence: 99%
“…On the one hand, α-synuclein overexpression restricts SARS-CoV-2 neuroinvasion and reduces the degeneration of dopaminergic neurons. On the other hand, the SARS-CoV-2 virus speeds up α-synuclein aggregation [ 64 ].…”
Section: Antimicrobial and Antiviral Properties Of Amyloidogenic Ppsmentioning
confidence: 99%
“…The biological plausibility for the role of infectious agents is supported by the known neurotropic effects of specific viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the susceptibility of the SN, inflammatory response, and the promotion of α-syn aggregation. 67 Thus, the antiviral strategy is of relevance for PD. 68 In this context, the well-known antiviral performance of GBNs 69 is favorable.…”
Section: The Potential Of Gbns In the Battle Against Pdmentioning
confidence: 99%
“…This effect mainly tends to arrest nucleation in the early stages and drive the conversion of preformed insoluble fibrils into soluble peptides that are later pushed across the BBB by efflux pumps, thus preventing neurodegeneration. 56 Moreover, since there is strong evidence of a link between SARS-COV-2 infection and PD, 67 GBNs such as GO or GQDs, beyond being inhibitors of a-syn aggregation due to antiviral activity, offer unique properties to combat PD. 114 The neuroprotection of GBNs also derives from control over protein misfolding attributed to enhanced clearance of aggregated proteins discussed above.…”
Section: Materials Advancesmentioning
confidence: 99%
“…[127] In addition, Nrf2 agonist sulforaphane reduces OS and normalizes autophagy in Parkinson's disease through inhibition generation of ROS and mTOR pathways, respectively. [71,128,129] Of note, advanced glycation end-products (AGEs) are implicated in the pathogenesis of acute and chronic inflammation and agingrelated atherosclerosis. [129][130][131][132][133] AGEs are typically produced during the aging process, though excessive production of AGEs is associated with vascular inflammation, atherosclerosis, OS, insulin resistance, and diabetes.…”
Section: Nrf2 Role In Inflammation and Immune Responsementioning
confidence: 99%