SARS-CoV-2 Infection in a Child with Severe Congenital Neutropenia

Vignesh, Pandiarajan; Mondal, Sanjib; Sudhakar, Murugan; Sharma, Yogish Kumar; Bansal, Arun; Singh, Mini P.; Sachdeva, Man Updesh Singh

doi:10.1007/s10875-021-01054-y

Cited by 7 publications

(15 citation statements)

References 10 publications

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“…Over the past 2 years, outcomes of SARS-CoV-2 infection have been reported for ∼1330 individuals with IEI. These studies range from reports of single cases or small numbers of patients 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 to cohort studies from Iran, 89 , 90 , 91 Turkey, 92 , 93 , 94 Brazil, 95 , 96 Israel, 97 Italy, 98 , 99 , 100 , 101 Spain, 102 the United Kingdom, 15 , 103 , 104 Mexico, 105 Denmark, 106 , 107 Poland, 108 …”

Section: Sars-cov-2 Infection Covid-19 and Ieimentioning

confidence: 99%

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Abel¹,

Al-Muhsen²,

Aiuti³

et al. 2023

Journal of Allergy and Clinical Immunology

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Section: Sars-cov-2 Infection Covid-19 and Ieimentioning

confidence: 99%

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Abel¹,

Al-Muhsen²,

Aiuti³

et al. 2023

Journal of Allergy and Clinical Immunology

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“…Among 34 patients with phagocyte defects reported, 22 had chronic granulomatous disease (CGD) ( 3 , 4 , 6 , 7 , 10 , 15 , 28 , 30 , 33 , 38 , 81 ). Two patients with CGD required ICU admission and eventually died due to Bulkolderia sepsis and uncontrolled MIS-C, respectively ( 4 , 6 ).…”

Section: Congenital Defects Of Phagocytesmentioning

confidence: 99%

COVID-19 and Inborn Errors of Immunity

2022

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Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evolution of COVID-19 in IEI patients. This review analyzes clinical outcomes following SARS-CoV-2 infection, as well as response to COVID-19 vaccines in patients with IEI.

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“…600 patients with previously diagnosed IEI. These include individual cases [27–53,87,88], experiences from single treatment centers [58,62,63,67,68], larger cohort studies from countries including Iran (19 patients) [69], Turkey (26 patients) [70], Brazil (121 patients) [71], Israel (20 patients) [72], Italy (131 patients) [73], UK (15 patients) [74], and Mexico (31 patients) [75], as well as an international survey of 94 patients from 12 countries across Europe, UK, Latin America, and the USA [76 ▪▪ ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms underlying host defense and disease pathology in response to severe acute respiratory syndrome (SARS)-CoV2 infection: insights from inborn errors of immunity

Tangye

Bucciol

Meyts

2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewThe severe acute respiratory syndrome (SARS)-coronavirus 2 (CoV2)/COVID-19 pandemic has reminded us of the fundamental and nonredundant role played by the innate and adaptive immune systems in host defense against emerging pathogens. The study of rare ‘experiments of nature’ in the setting of inborn errors of immunity (IEI) caused by monogenic germline variants has revealed key insights into the molecular and cellular requirements for immune-mediated protection against infectious diseases. This review will provide an overview of the discoveries obtained from investigating severe COVID-19 in patients with defined IEI or otherwise healthy individuals.Recent findingsGenetic, serological and cohort studies have provided key findings regarding host defense against SARS-CoV2 infection, and mechanisms of disease pathogenesis. Remarkably, the risk factors, severity of disease, and case fatality rate following SARS-CoV2 infection in patients with IEI were not too dissimilar to that observed for the general population. However, the type I interferon (IFN) signaling pathway – activated in innate immune cells in response to viral sensing – is critical for anti-SARS-CoV2 immunity. Indeed, genetic variants or autoAbs affecting type I IFN function account for up to 20% of all cases of life-threatening COVID-19.SummaryThe analysis of rare cases of severe COVID-19, coupled with assessing the impact of SARS-CoV2 infection in individuals with previously diagnosed IEI, has revealed fundamental aspects of human immunology, disease pathogenesis and immunopathology in the context of exposure to and infection with a novel pathogen. These findings can be leveraged to improve therapies for treating for emerging and established infectious diseases.

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SARS-CoV-2 Infection in a Child with Severe Congenital Neutropenia

Cited by 7 publications

References 10 publications

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

COVID-19 and Inborn Errors of Immunity

Mechanisms underlying host defense and disease pathology in response to severe acute respiratory syndrome (SARS)-CoV2 infection: insights from inborn errors of immunity

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