SARS‐CoV‐2 intralineage variation and temporal patterns of COVID‐19 risk factors in three cities of southeastern Brazil: Age, sex, and race

Abstract

The Santo André Regional Center from Adolfo Lutz Institute evaluated 91 537 samples by reverse transcription-polymerase chain reaction (RT-PCR) to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from March 2020 to April 2021. The age, sex, and race of patients from three cities in southeastern Brazil, namely São Bernardo do Campo (SBC), Diadema, and Mauá were assessed in association to the rate of positive results using generalized linear models. Circulating lineages were obtained from GISAID and intralineage genetic variation was investigated employing Lasergene software. A declining number of reported cases around October to November 2020 separate two epidemic waves in the three cities.Mauá differed by the highest positive RT-PCR scores in January and February.GISAID classification of 38 SARS-CoV-2 complete genomic sequences showed the