SARS-COV-2 NSP5 Antagonizes MHC II Expresion by Subverting Histone Deacetylase 2

Taefehshokr, Nima; Lac, Alex; Vrieze, Angela M.; Dickson, Brandon H; Guo, Peter N; Jung, Catherine; Blythe, Eoin N; Fink, Corby; Dikeakos, Jimmy D.; Dekaban, Gregory A.; Heit, Bryan

doi:10.1101/2023.02.10.528032

Cited by 2 publications

(1 citation statement)

References 126 publications

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“…Both mechanisms propose epigenetic changes that modulate resource availability and it could be complicated to assess the correctness of either of those. However, epigenetic changes occur post SARS-Cov2 infection [56], and manipulation of epigenetic machinery such as HDAC2 has already been reported [57]. Therefore epigenetic modifications are a result of SASR-Cov2 infection but its meaning remains to be addressed.…”

Section: Post Acute Sequelaementioning

confidence: 99%

SARS-Cov2 seasonality and adaptation are driven by solar activity.

Gonzalez-Lugo¹

2023

Preprint

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Since its isolation in Wuhan SARS-Cov2 showed a high mutation rate hindering the ability to properly characterize. Also as a consequence of its size, traditional sequence analysis methods were computationally constrained. However, applying variational autoencoders (VAEs) to custom sequence representations results in a series of clusters sorted by the sunshine duration (SD) rate of change (SDRC) and other solar-derived features. The transition between clusters is characterized by changes in viral genome size, apparent deletions can be found throughout the SARS-Cov2 genome. This series of deletions might behave as an internal clock inside the genome. SDRC-derived features synchronize COVID-19 cases into a single period. Both SDRC-derived features and solar features correlate with COVID-19 cases pointing towards a solar-dependent seasonality. Atmospheric changes that affect solar radiation also showed a correlation with COVID-19 cases. Analyzing viral genome composition as time series displays an attractor-like behavior under different solar-derived time scales. While clustering them by environmental conditions shows a similar pattern as the one found by the VAE models. Further development of analysis techniques will help us to better understand the seasonality and adaptation of pathogenic organisms.

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Section: Post Acute Sequelaementioning

confidence: 99%

SARS-Cov2 seasonality and adaptation are driven by solar activity.

Gonzalez-Lugo¹

2023

Preprint

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Therapeutic targeting ofTGF‐β in lung cancer

Aftabi,

Barzegar Behrooz,

Cordani

et al. 2024

The FEBS Journal

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Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology, initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its role evolves in the advanced stages of the disease, where it contributes to tumor progression not by directly promoting cell proliferation but by enhancing epithelial–mesenchymal transition (EMT) and creating a conducive tumor microenvironment. While EMT is typically associated with enhanced migratory and invasive capabilities rather than proliferation per se, TGF‐β's influence on this process facilitates the complex dynamics of tumor metastasis. Additionally, TGF‐β impacts the tumor microenvironment by interacting with immune cells, a process influenced by genetic and epigenetic changes within tumor cells. This interaction highlights its role in immune evasion and chemoresistance, further complicating lung cancer therapy. This review provides a critical overview of recent findings on TGF‐β's involvement in lung cancer, its contribution to chemoresistance, and its modulation of the immune response. Despite the considerable challenges encountered in clinical trials and the development of new treatments targeting the TGF‐β pathway, this review highlights the necessity for continued, in‐depth investigation into the roles of TGF‐β. A deeper comprehension of these roles may lead to novel, targeted therapies for lung cancer. Despite the intricate behavior of TGF‐β signaling in tumors and previous challenges, further research could yield innovative treatment strategies.

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SARS-COV-2 NSP5 Antagonizes MHC II Expresion by Subverting Histone Deacetylase 2

Cited by 2 publications

References 126 publications

SARS-Cov2 seasonality and adaptation are driven by solar activity.

SARS-Cov2 seasonality and adaptation are driven by solar activity.

Therapeutic targeting ofTGF‐β in lung cancer

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