2024
DOI: 10.1080/22221751.2024.2359004
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SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1

Qian Wang,
Yicheng Guo,
Logan T. Schwanz
et al.

Abstract: As SARS-CoV-2 continues to spread and mutate, tracking the viral evolutionary trajectory and understanding the functional consequences of its mutations remain crucial. Here, we characterized the antibody evasion, ACE2 receptor engagement, and viral infectivity of the highly mutated SARS-CoV-2 Omicron subvariant BA.2.87.1. Compared with other Omicron subvariants, including EG.5.1 and the current predominant JN.1, BA.2.87.1 exhibits less immune evasion, reduced viral receptor engagement, and comparable infectivi… Show more

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“…KP.2 is characterized by the mutations R346T, F456L, and V1104L, whereas KP.3 exhibits F456L, Q493E, and V1104L. Remarkably, both dominant variants share the F456L mutation, again demonstrating that antibody evasion is a major selective advantage for viral growth in the population, as we and others have repeatedly observed over the past few years for successive variants and subvariants of SARS-CoV-2 1,8,3436 .…”
Section: Discussionsupporting
confidence: 55%
“…KP.2 is characterized by the mutations R346T, F456L, and V1104L, whereas KP.3 exhibits F456L, Q493E, and V1104L. Remarkably, both dominant variants share the F456L mutation, again demonstrating that antibody evasion is a major selective advantage for viral growth in the population, as we and others have repeatedly observed over the past few years for successive variants and subvariants of SARS-CoV-2 1,8,3436 .…”
Section: Discussionsupporting
confidence: 55%