2024
DOI: 10.1101/2024.04.23.590789
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SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

Susanne Klute,
Rayhane Nchioua,
Arne Cordsmeier
et al.

Abstract: To date, five variants of concern (VOCs) of SARS-CoV-2 have emerged that show increased fitness and/or immune evasion. While the continuously evolving escape from humoral immune responses has been analyzed in detail, adaptation of SARS-CoV-2 to human innate immune defenses such as autophagy is less understood. Here, we demonstrate that mutation T9I in the structural envelope (E) protein confers autophagy resistance of Omicron VOCs (BA.1, BA.5 and XBB.1.5) compared to 2020 SARS-CoV-2 or the Delta VOC. Mechanist… Show more

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