SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies

Tang, Wen-Fang; Anh, Tu Tran; Ly, Wang; Horng, Jim-Tong

doi:10.1016/j.bj.2023.02.007

Cited by 5 publications

(4 citation statements)

References 98 publications

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“… 716 CRISPR-based detection systems, such as SHERLOCK, DETECTR, and STOPCovid, are becoming important emerging tools for viral detection due to their speed, specificity, and ease of use. 717 It should be noted that the SHERLOCK test kit and DETECTR test kit have received EUA from the U.S. FDA and can be used for the detection of the SARS-CoV-2 virus. The latest generation of SHERLOCK technology enables faster (30–60 min) and more sensitive (240 nM) assays with minimal reaction system (1ul) and lower mismatch rates than traditional PCR technologies.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…These carriers serve as vehicles to transport therapeutic agents to the target site [86], enhance drug stability [52], improve drug solubility [45], and provide controlled release profiles [87]. Some commonly used carriers in drug delivery systems for SARS-CoV-2-related diseases include lipid-based nanoparticles [83], polymeric nanoparticles [93], polymer-based hydrogels [94], viral vectors [49], nanocarriers [83], and anti-body-drug conjugates (ADCs) [95] as illustrated in Figure 4. Polymer-based hydrogels used as carriers in drug delivery systems for the treatment of disease related to SARS-CoV-2 virus are conjugated polymers [94].…”

Section: Carriers In Drug Delivery Systems Formentioning

confidence: 99%

“…delivery systems for disease treatment related to SARS-CoV-2 virus Antibody-drug conjugates (ADCs) are a type of drug delivery system used for disease treatment, including those related to the SARS-CoV-2 virus. ADCs combine the specificity of antibodies with the cytotoxicity of drugs, allowing for targeted delivery of potent therapeutic agents to specific cells or tissues [95]. ADCs consist of three main components: a monoclonal antibody [125], a linker [126], and a cytotoxic drug [127].…”

Section: Antibody-drug Conjugates (Adcs) In Drugmentioning

confidence: 99%

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

Hoc Thang,

Van Phuc,

Nhi

et al. 2024

Express Polym. Lett.

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The COVID-19 pandemic has presented an array of challenges and given rise to a spectrum of diseases and health issues [1]. Foremost among the challenges of the pandemic is the swift transmission of the SARS-CoV-2 virus [2]. Strategies to curb transmission encompass extensive vaccination campaigns [3], the implementation of public health measures like mask-wearing [4] and social distancing [4], and the promotion of hygiene practices such as frequent handwashing [5]. The SARS-CoV-2 virus, which causes COVID-19, primarily targets the respiratory system [6]. However, it can also precipitate various complications and impact other organs and bodily systems [7]. COVID-19, an abbreviation for Coronavirus Disease 2019, is the ailment brought about by the SARS-CoV-2 virus [8]. It manifests as a broad spectrum of symptoms, spanning from mild to severe respiratory ailments [9]. Common symptoms include fever, cough, shortness of breath, fatigue, loss of taste or smell, and body aches [10]. In severe instances, it can progress to pneumonia and acute

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“…provide an update of CRISPR in diagnosis and host–virus interaction studies. They present Cas-based detection methods that provide advantages in terms of speed and specificity, Cas-crRNA complexes that have been shown to reduce viral loads in vivo , and CRISPR knockout and activation screenings results revealing vital pathways of the coronavirus life cycle [ 22 ].…”

Section: Also In This Issuementioning

confidence: 99%

When it doesn't run in the blood(vessels) – events involved in vascular disorders

Kattner¹

2023

Biomedical Journal

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SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies

Cited by 5 publications

References 98 publications

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

When it doesn't run in the blood(vessels) – events involved in vascular disorders

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