SARS-CoV-2 Re-Infection versus Prolonged Shedding: A Case Series

Nicholson, Erin; Avadhanula, Vasanthi; Fragoso, Sonia; Stroh, Rachel; Ye, Xunyan; Bond, Nanette; Santarcangelo, Patricia; Stroh, John; Piedra, Pedro A.

doi:10.22541/au.162117356.65294411/v1

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Currently, there is a study to distinguish prolonged shedding of SARS-CoV-2 viral RNA from true reinfection. This study supports the notion that primary SARS-CoV-2 reinfection is unlikely within 90 days of symptom onset (Nicholson et al, 2021). In this case, symptoms reappeared within 90 days of the onset of primary SARS-CoV-2 infection symptoms; therefore, it can be concluded that the patient was not reinfected.…”

Section: Discussionsupporting

confidence: 88%

Coinfection of SARS-CoV-2 and influenza A (H3N2) detected in bronchoalveolar lavage fluid of a patient with long COVID using metagenomic next−generation sequencing: a case report

Liang,

Wang,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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The growing number of long COVID cases has drawn clinical attention to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has been spreading worldwide since winter 2019. Its symptoms are not limited to fatigue and shortness of breath but also affect daily life. We report the use of metagenomic next-generation sequencing (mNGS) to detect coinfection with SARS-CoV-2 and influenza A virus in a patient with long COVID. The patient was admitted with fever, expectoration, fatigue, and shortness of breath. The PCR test was negative due to possible clearance of SARS-Cov-2 in the upper respiratory tract of patients with long COVID. Other routine microbiological tests were also negative, making the clinical diagnosis difficult. Bronchoalveolar lavage fluid (BALF) samples were tested using mNGS. The patient was diagnosed and treated promptly, recovered quickly, and continued taking azvudine after discharge; his condition was stable. This study illustrates that mNGS may be valuable for the timely diagnosis of patients with long COVID and their mixed infections.

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Section: Discussionsupporting

confidence: 88%

Coinfection of SARS-CoV-2 and influenza A (H3N2) detected in bronchoalveolar lavage fluid of a patient with long COVID using metagenomic next−generation sequencing: a case report

Liang,

Wang,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

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SARS-CoV-2 Reinfection Is a New Challenge for the Effectiveness of Global Vaccination Campaign: A Systematic Review of Cases Reported in Literature

Muzio

Ambosino

Muzio

et al. 2021

IJERPH

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Reinfection with SARS-CoV-2 seems to be a rare phenomenon. The objective of this study is to carry out a systematic search of literature on the SARS-CoV-2 reinfection in order to understand the success of the global vaccine campaigns. A systematic search was performed. Inclusion criteria included a positive RT-PCR test of more than 90 days after the initial test and the confirmed recovery or a positive RT-PCR test of more than 45 days after the initial test that is accompanied by compatible symptoms or epidemiological exposure, naturally after the confirmed recovery. Only 117 articles were included in the final review with 260 confirmed cases. The severity of the reinfection episode was more severe in 92/260 (35.3%) with death only in 14 cases. The observation that many reinfection cases were less severe than initial cases is interesting because it may suggest partial protection from disease. Another interesting line of data is the detection of different clades or lineages by genome sequencing between initial infection and reinfection in 52/260 cases (20%). The findings are useful and contribute towards the role of vaccination in response to the COVID-19 infections. Due to the reinfection cases with SARS-CoV-2, it is evident that the level of immunity is not 100% for all individuals. These data highlight how it is necessary to continue to observe all the prescriptions recently indicated in the literature in order to avoid new contagion for all people after healing from COVID-19 or becoming asymptomatic positive.

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SARS-CoV-2 Re-Infection versus Prolonged Shedding: A Case Series

Cited by 2 publications

References 11 publications

Coinfection of SARS-CoV-2 and influenza A (H3N2) detected in bronchoalveolar lavage fluid of a patient with long COVID using metagenomic next−generation sequencing: a case report

Coinfection of SARS-CoV-2 and influenza A (H3N2) detected in bronchoalveolar lavage fluid of a patient with long COVID using metagenomic next−generation sequencing: a case report

SARS-CoV-2 Reinfection Is a New Challenge for the Effectiveness of Global Vaccination Campaign: A Systematic Review of Cases Reported in Literature

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