SARS-CoV-2-related pangolin coronavirus exhibits similar infection characteristics to SARS-CoV-2 and direct contact transmissibility in hamsters

Guo, Zhixin; Zhang, Cheng; Zhang, Chunmao; Chen, Zhaoliang; Jiang, Xinyun; Wang, Tiecheng; Li, Yuanguo; Li, Jun; Wan, Zhonghai; Meng, Keyin; Li, Jiping; Tong, Yigang; Gao, Yuwei

doi:10.1016/j.isci.2022.104350

Cited by 19 publications

(22 citation statements)

References 21 publications

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“…Omicron is seen as more infectious as the result of its unusually low PID M . At least two laboratories [ 44 , 45 ] have also experimentally discovered that the 2017 pangolin-CoV is attenuated, as seen in Figure 7 .…”

Section: Resultsmentioning

confidence: 99%

“…In this paper, correlations with statistical significance are presented using more complete data available from [ 43 ]. Furthermore, data showing the viral titer of pangolin-CoV-2017 in comparison to that of SARS-CoV-2 were not available then [ 44 , 45 ]. Additionally, shell disorder analysis was yet to be performed on the COVID-19-related sequence obtained from bats in Laos [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

Goh¹,

Dunker

Foster

et al. 2022

Biomolecules

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The basic tenets of the shell disorder model (SDM) as applied to COVID-19 are that the harder outer shell of the virus shell (lower PID—percentage of intrinsic disorder—of the membrane protein M, PIDM) and higher flexibility of the inner shell (higher PID of the nucleocapsid protein N, PIDN) are correlated with the contagiousness and virulence, respectively. M protects the virion from the anti-microbial enzymes in the saliva and mucus. N disorder is associated with the rapid replication of the virus. SDM predictions are supported by two experimental observations. The first observation demonstrated lesser and greater presence of the Omicron particles in the lungs and bronchial tissues, respectively, as there is a greater level of mucus in the bronchi. The other observation revealed that there are lower viral loads in 2017-pangolin-CoV, which is predicted to have similarly low PIDN as Omicron. The abnormally hard M, which is very rarely seen in coronaviruses, arose from the fecal–oral behaviors of pangolins via exposure to buried feces. Pangolins provide an environment for coronavirus (CoV) attenuation, which is seen in Omicron. Phylogenetic study using M shows that COVID-19-related bat-CoVs from Laos and Omicron are clustered in close proximity to pangolin-CoVs, which suggests the recurrence of interspecies transmissions. Hard M may have implications for long COVID-19, with immune systems having difficulty degrading viral proteins/particles.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

Goh¹,

Dunker

Foster

et al. 2022

Biomolecules

View full text Add to dashboard Cite

show abstract

“…Griffin et al reported that the North American deer mouse might be another host of SARS-CoV-2 (Griffin et al 2021 ). Guo et al reported that the hamsters are additional hosts of SARS-CoV-2 (Guo et al 2022 ). Thus, it might create the ambiguities surrounding the animal origin of COVID-19 that continues to puzzle the scientific community at large.…”

Section: The Origin Of Ongoing Pandemic Virus Sars-cov-2: Is It Still...mentioning

confidence: 99%

Appearance and re-appearance of zoonotic disease during the pandemic period: long-term monitoring and analysis of zoonosis is crucial to confirm the animal origin of SARS-CoV-2 and monkeypox virus

Chakraborty

Bhattacharya

Nandi

et al. 2022

Veterinary Quarterly

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“… 170 , 183 , 187 As in humans, low levels of SARS‐CoV‐2 (A‐D) can be detected on occasion in the brains of non‐human primates 37 , 186 and ferrets. 40 , 43 SARS‐CoV‐2 (A‐D) RNA is plentiful in the brains of young hamsters 36 , 53 , 175 but has yet to be detected in the brains of infected standard laboratory adult mice 137 , 138 , 188 and adult hamsters. 53 Further research is needed to assess whether SARS‐CoV‐2 RNA can be detected in the brains of aged rodents to recapitulate human disease.…”

Section: Sars‐cov‐2 Preferentially Targets Non‐neuronal Cellsmentioning

confidence: 99%

“…34,35 Such a polybasic site has never been detected in pangolin-derived sarbecoronaviruses thus far, which may explain why pangolin-derived sarbecoronaviruses fail to be transmitted through aerosol and replicate efficiently in other mammalian hosts. 36 Therefore, the natural acquisition of SARS-CoV-2's polybasic site remains a mystery, and the lack of data on SARS-like sarbecoronavirus carrying this polybasic site leaves room for conspiracies of SARS-CoV-2 being initially created in a laboratory setting. 7,27 The mutation-dependent evolutionary plasticity of SARS-like sarbecoronaviruses binding ACE2 orthologs is remarkable, which explains the high zoonotic capabilities of these viruses.…”

Section: The Emergence and Evolution Of Sars-cov-2mentioning

confidence: 99%

The nervous system during COVID‐19: Caught in the crossfire

Natale

Lukens

Petri

2022

Immunological Reviews

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SUMMARY SARS‐CoV‐2, the virus that causes coronavirus disease (COVID)‐19, has become a persistent global health threat. Individuals who are symptomatic for COVID‐19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID‐19 patients display long‐term neurological disorders postinfection such as cognitive decline, which emphasizes the need to further elucidate the effects of COVID‐19 on the central nervous system. In this review article, we summarize an emerging body of literature describing the impact of SARS‐CoV‐2 infection on central nervous system (CNS) health and highlight important areas of future investigation.

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SARS-CoV-2-related pangolin coronavirus exhibits similar infection characteristics to SARS-CoV-2 and direct contact transmissibility in hamsters

Cited by 19 publications

References 21 publications

A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

Appearance and re-appearance of zoonotic disease during the pandemic period: long-term monitoring and analysis of zoonosis is crucial to confirm the animal origin of SARS-CoV-2 and monkeypox virus

The nervous system during COVID‐19: Caught in the crossfire

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