SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts

Chirathaworn, Chintana; Sripramote, Manit; Chalongviriyalert, Piti; Jirajariyavej, Supunee; Kiatpanabhikul, Phatharaporn; Saiyarin, Jatuporn; Soudon, Chulikorn; Thienfaidee, Orawan; Ayuthaya, Thitisan Palakawong Na; Brukesawan, Chantapat; Chaiwanichsiri, Dootchai; Intharasongkroh, Duangnapa; Wanlapakorn, Nasamon; Chansaenroj, Jira; Puenpa, Jiratchaya; Yorsaeng, Ritthideach; Thitithanyanont, Arunee; Kitphati, Rungrueng; Mungaomklang, Anek; Nagavajara, Pijaya; Poovorawan, Yong

doi:10.1101/2020.07.17.208439

Cited by 8 publications

(9 citation statements)

References 27 publications

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“…Although the scientific community is aware of the general immune response after any viral infection, the information about immune response during and after covid19 infection is still largely evolving. 10 Multiple sero-surveillance studies which have focused on antibodies against SARS-CoV2 among various categories have been found to be extremely useful in understanding the progress of the pandemic. Scientific studies have recommended continued surveillance through seroprevalence studies to estimate and monitor the growing burden of Covid-19.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV2 IgG antibody: Seroprevalence among health care workers

Prakash¹,

Solanki²,

Sheth³

et al. 2021

Clinical Epidemiology and Global Health

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Background Health Care Workers (HCWs) are at higher risk for Covid19. Sero-surveillance among HCWs using IgG antibodies can add further value to the scientific findings. Objectives To estimate seropositivity among HCWs and to correlate it with various factors affecting seropositivity. Methods Population based large scale sero-surveillance among HCWs was carried out during second half of August’20 in Ahmedabad using “Covid-Kavach” IgG Antibody Detection ELISA kits. Seropositivity among HCWs was estimated and compared with various demographic & other factors to understand their infection & immunity status. Proportions and Z-test were used as appropriate. Results As on August’20, Seropositivity among HCWs from Ahmedabad is 23.65% (95% Confidence Interval 21.70–25.73%). Seropositivity of 25.98% (95%CI 23.47–28.66) among female HCWs is significantly higher than 19.48% (95%CI 16.53–22.80) among male HCWs. The zone wise positivity among HCWs closely correlate with cases reported from the respective zone. The sero-positivity among HCWs from the earliest and worst affected zones have lower level of seropositivity as compared to the zones affected recently. This might be pointing towards the fact that the IgG Antibodies may not be long lasting. Conclusion As on August 2020, the seropositivity of 23.65% in HCWs indicate high level of disease transmission and higher risk of infection among HCWs in Ahmedabad. The seropositivity is significantly higher among female HCWs. Zone wise seropositivity, closely correlate with the reported cases from the respective zone. Their comparison also indicates the possibility of reducing IgG seropositivity, which necessitates further in-depth scientific research to generate greater scientific evidences.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV2 IgG antibody: Seroprevalence among health care workers

Prakash¹,

Solanki²,

Sheth³

et al. 2021

Clinical Epidemiology and Global Health

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“…As of 15 December 2020, more than 73 million people have been infected with SARS-CoV-2 and over 1.6 million deaths have been reported worldwide (Worldometer, 2021). Viral RNA can remain detectable for more than 100 days in 6.6% of patients after clinical recovery from initial infection; 5% their close contacts develop IgG antibodies, suggesting past exposure (Chirathaworn et al, 2020). Asymptomatic people are also well-documented transmitters of infection.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 infection in mortuary and cemetery workers

Alishaq¹,

Jeremijenko²,

Nafady-Hego³

et al. 2021

International Journal of Infectious Diseases

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Background: Mortuary and cemetery workers may be exposed to the bodies of people with SARS-CoV-2 infection; however, prevalence of infection among these groups is unknown. Methods: Nasopharyngeal swabs (NPS) for RT-PCR and serologic testing for SARS-CoV-2 were performed on mortuary and cemetery workers in Qatar. Data on specific job duties, living conditions, contact history, and clinical course were gathered. Environmental sampling was carried out to explore any association with infection. Logistic regression analysis was used to determine the factors associated with infection. Results: Forty-seven mortuary workers provided an NPS and seven (14.9%) were PCR positive; 32 provided a blood sample and eight (25%) were antibody positive, six (75%) who were seropositive were also PCR positive. Among the 81 cemetery workers, 76 provided an NPS and five (6.6%) were PCR positive; 64 provided a blood sample and 22 (34.4%) were antibody positive, three (13.6%) who were seropositive were also PCR positive. Three (22.2%) and 20 (83.3%) of the infected mortuary and cemetery workers were asymptomatic, respectively. Age <30 years (OR 4.9, 95% CI 1.7-14.6), community exposure with a known case (OR 4.7, 95% CI 1.7-13.3), and presence of symptoms in the preceding 2 weeks (OR 9.0, 95% CI 1.9-42.0) were independently associated with an increased risk of infection (PCR or antibody positive). Of the 46 environmental and surface samples, all were negative or had a Ct value of >35. Conclusion: A substantial proportion of mortuary and cemetery workers had evidence of SARS-CoV-2 infection, which was incidentally detected upon serologic testing. These data are most consistent with community acquisition rather than occupational acquisition.

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“…Although the scientific community is aware of the general immune response after any viral infection, and has some insight into the seropositivity for Covid19, there is very little information about the immune response among Contacts of Covid19 cases. 14,15 The present study on the seropositivity among contacts is among the few serological studies from India, exclusively covering the contacts of Covid19 cases with a large sample of contacts.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Immunoglobulin G Antibody among Contacts of COVID19 Cases: A Study from India

Prakash

Solanki

Sheth

et al. 2022

J Health Sci Med Res

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Objective: To estimate Covid19 seropositivity among contacts of cases and to compare the seropositivity among different types of contact for assessing the differential risk & transmission dynamics.Material and Methods: A large-scale population-based serosurvey was carried out among the general population of Ahmedabad during the second half of October 2020. The contacts of cases were selected based on the population proportion and enrolled as an additional category. The seropositivity among the contacts was estimated using the enzyme-linked immunosorbent assay and compared with different types of contact and available demographic factors.Results: As of October 2020, the seropositivity against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2) among contacts of cases in Ahmedabad was 26.0% [95% confidence interval 24.2–28.0]. The seropositivity among family contacts was significantly higher (28.8%) compared to other contacts (24.4%) (Z=2.19, p-value=0.028). This trend was seen across all age groups and both sexes. The seropositivity was higher among females (27.7%) compared to males (24.5%) but the difference was statistically not significant (Z=1.64, p-value=0.101). In terms of age groups, the positivity had an increasing trend up to 60 years but declined after that.Conclusion: A seropositivity of 26.0% among contacts indicates that a large proportion of contacts demonstrated Immunoglobulin-G antibodies. This highlights asymptomatic transmission and/or low sensitivity of the diagnostic tests. The current strategy for contact tracing and testing among contacts is justified based on the significantly higher seropositivity among family contacts.

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SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts

Cited by 8 publications

References 27 publications

SARS-CoV2 IgG antibody: Seroprevalence among health care workers

SARS-CoV2 IgG antibody: Seroprevalence among health care workers

SARS-CoV-2 infection in mortuary and cemetery workers

Seroprevalence of Immunoglobulin G Antibody among Contacts of COVID19 Cases: A Study from India

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