SARS‐CoV‐2 RNAaemia in children: An Iranian referral hospital‐based study

Pourakbari, Babak; Mahmoudi, Shima; Mahmoudieh, Yasmine; Eshaghi, Hamid; Navaeian, Amene; Rostamyan, Maryam; Mamishi, Setareh

doi:10.1002/jmv.27065

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising [ 1 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

et al. 2022

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Background The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases. Methods This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2. Results Among the 262 patients with suspected COVID-19, 142 confirmed COVID-19 cases were included in the study. A total of 11 children were diagnosed as MIS-C. The majority of the cases with MIS-C were male, (n = 9, 82%) which is significantly higher than children (n = 61, 47%) with acute COVID-19 (P = 0.03). Fifty patients (35%) were shown to have a more severe form of COVID-19. Ninety percent of the cases (n = 45) with severe COVID-19 had comorbidities that was significantly higher than cases with non-severe or mild disease (n = 41, 45%; P < 0.0001). A mortality rate of 10% was reported (n = 14). Ninety-three percent of the deceased cases (n = 13) had comorbidities that were significantly higher than discharged patients (n = 73, 57%; P = 0.009). Conclusion The increasing number of children with severe COVID-19 is cause for great concern. Underlying diseases, mainly cardiovascular diseases, cancer, and malignancies, are associated with greater risk of development of severe COVID-19 and even death in children. On the other hand, pediatric patients with MIS-C usually develop a milder form of the disease. However, evaluation specific immunological responses in children to explore the delayed inflammatory syndrome are highly recommended.

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Section: Introductionmentioning

confidence: 99%

Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

et al. 2022

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“…Studies published in many countries showed that SARS-CoV-2 RNA was detected in the blood, plasma, or serum [22][23][24][25][26]. Huang et al [23] reported that there were 6 cases (15%) of SARS-CoV-2 RNA positive in the blood among 41 SARS-CoV-2 patients in Wuhan, China, and the median PCR cycle threshold was 35.1 (95% CI: 34.7-35.1), indicating that the RNA concentration was very low.…”

Section: Sars-cov-2 Infection and Blood Safetymentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Blood Safety

He¹,

Shi

Li³

et al. 2022

Acta Haematol

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Since the outbreak of SARS-CoV-2, it has spread rapidly around the world and caused a serious global social crisis. During the epidemic, the blood collection and supply industry have been greatly impacted, due to the sharply dropped blood donors and transfusion transmission risk of SARS-CoV-2. Many infected individuals are asymptomatic and they may donate blood without awareness of the infection or before symptoms appear. In addition, viral RNAs have been detected in the blood of some patients infected with SARS-CoV-2. Although no infectious SARS-CoV-2 virus was found in the blood nor the blood components, there is a risk of transmission through blood transfusion which may endanger blood safety, especially during the pandemic period. This review briefly introduces the biological characteristics, epidemiology of SARS-CoV-2, with a particular focus on SARS-CoV-2 infection and blood safety.

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“…It was found that the most common symptoms reported in children, i.e., <18 years old, are cough and dyspnea ( Rabizadeh et al, 2020 ; Fahimzad et al, 2021 ) and fever and cough ( Hosseninasab et al, 2020 ; Mahmoudi et al, 2020 ; Armin et al, 2021 ; Hoseinyazdi et al, 2021 ; Mamishi et al, 2021 ; Soleimani et al, 2021 ; Keshavarz Valian et al, 2022 ). Gastrointestinal symptoms including vomiting, nausea, and diarrhea were reported but to a lesser extent ( Hosseninasab et al, 2020 ; Mamishi et al, 2020 ; Armin et al, 2021 ; Fahimzad et al, 2021 ; Pourakbari et al, 2021 ). Interestingly, neurological symptoms such as seizure, fatigue, and headache were also described ( Cheraghali et al, 2021 ; Fahimzad et al, 2021 ).…”

Section: Childrenmentioning

confidence: 99%

“…In COVID-19 children, compared to those admitted to the general ward, ICU patients had more acute respiratory distress syndrome, shock, and acute cardiac injury as complications ( Fahimzad et al, 2021 ). The mortality rate appears to be low in infected children of Iran ( Hosseninasab et al, 2020 ; Armin et al, 2021 ; Hoseinyazdi et al, 2021 ; Mamishi et al, 2021 ; Pourakbari et al, 2021 ), ranging from 0 death ( Esmaeili Dooki et al, 2020 ; Soleimani et al, 2021 ) to 11% ( Mahmoudi et al, 2020 ; Mamishi et al, 2020 ; Armin et al, 2021 ). Interestingly, in one study the mortality rate was 20%, however, this was in children with underlying malignancies, namely acute lymphocytic and acute myeloid leukemia ( Navaeian et al, 2021 ).…”

Section: Childrenmentioning

confidence: 99%

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

Dandachi

Aljabr

2022

Front. Microbiol.

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Since its emergence in China in 2019, the SARS-CoV-2 virus has affected all countries worldwide. The virus is easily transmitted from one person to another via infected aerosols or contaminated surfaces. Unlike its counterparts, the prognosis of COVID-19 ranges from asymptomatic to critical disease or death. Several factors play a role in determining the severity of the disease in infected patients. Among others, is the pre-existence of an underlying medical condition such as diabetes, cancer, and others. Furthermore, although children are less prone to the severe form of the COVID-19 disease, they require attention due to the report of many atypical presentations of the infection, post-asymptomatic exposure. In the Middle East, little is known about the prognosis of the SARS-CoV-2 infection in high-risk categories, notably patients with diabetes, cancer, and pregnant women. The aim of this review is to summarize the current knowledge about this group of population in the middle eastern region as well as to highlight the gap in the literature. We have found that the majority of the papers were from the Gulf countries. Although, few studies were conducted; high-risk patients appear to have an increased risk of morbidity and mortality from COVID-19 compared to their counterparts. Higher levels of inflammatory markers, C-reactive protein, erythrocyte sedimentation rate, D-dimer, and ferritin levels were also observed. Children are often asymptomatic or present with atypical presentations. More studies should be conducted to determine the clinical biomarkers of COVID-19 in high-risk categories to help in patient risk stratification and management in the middle eastern population.

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SARS‐CoV‐2 RNAaemia in children: An Iranian referral hospital‐based study

Cited by 15 publications

References 22 publications

Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Blood Safety

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

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