SARS-COV-2 seroprevalence among all healthcare workers in a tertiary hospital in Spain

Cantero, Mireia; Millán-Pérez, Rosario; Múñez, Elena; Gómez‐Lozano, Natalia; Anel-Pedroche, Jorge; Parra, Lina M.; Rodríguez, María Luisa Fernández; Asensio, Ángel

doi:10.1080/23744235.2021.1963468

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…Varona et al performed a cross-sectional study evaluating 6038 employees from the healthcare system of 17 hospitals across four regions in Spain (Madrid, Catalonia, Galicia and Castilla-Leon), showing an 11% seropositivity for SARS-CoV-2 IgG 16. Finally, other studies in Madrid reported a seroprevalence between 16.6% and 36.5% among HCW in areas with high COVID-19 prevalence 17–19. These studies revealed seroprevalence of SARS-CoV-2 IgG antibodies in HCW tend to be higher than in the general population, at variance according to regional COVID-19 incidence.…”

Section: Discussionmentioning

confidence: 98%

COVID-19 among workers of a comprehensive cancer centre between first and second epidemic waves (2020): a seroprevalence study in Catalonia, Spain

et al. 2022

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ObjectivesPatients with cancer are at higher risk for severe COVID-19 infection. COVID-19 surveillance of workers in oncological centres is crucial to assess infection burden and prevent transmission. We estimate the SARS-CoV-2 seroprevalence among healthcare workers (HCWs) of a comprehensive cancer centre in Catalonia, Spain, and analyse its association with sociodemographic characteristics, exposure factors and behaviours.DesignCross-sectional study (21 May 2020–26 June 2020).SettingA comprehensive cancer centre (Institut Català d’Oncologia) in Catalonia, Spain.ParticipantsAll HCWs (N=1969) were invited to complete an online self-administered epidemiological survey and provide a blood sample for SARS-CoV-2 antibodies detection.Primary outcome measurePrevalence (%) and 95% CIs of seropositivity together with adjusted prevalence ratios (aPR) and 95% CI were estimated.ResultsA total of 1266 HCWs filled the survey (participation rate: 64.0%) and 1238 underwent serological testing (97.8%). The median age was 43.7 years (p25–p75: 34.8–51.0 years), 76.0% were female, 52.0% were nursing or medical staff and 79.0% worked on-site during the pandemic period. SARS-CoV-2 seroprevalence was 8.9% (95% CI 7.44% to 10.63%), with no differences by age and sex. No significant differences in terms of seroprevalence were observed between onsite workers and teleworkers. Seropositivity was associated with living with a person with COVID-19 (aPR 3.86, 95% CI 2.49 to 5.98). Among on-site workers, seropositive participants were twofold more likely to be nursing or medical staff. Nursing and medical staff working in a COVID-19 area showed a higher seroprevalence than other staff (aPR 2.45, 95% CI 1.08 to 5.52).ConclusionsAt the end of the first wave of the pandemic in Spain, SARS-CoV-2 seroprevalence among Institut Català d’Oncologia HCW was lower than the reported in other Spanish hospitals. The main risk factors were sharing household with infected people and contact with COVID-19 patients and colleagues. Strengthening preventive measures and health education among HCW is fundamental.

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Section: Discussionmentioning

confidence: 98%

COVID-19 among workers of a comprehensive cancer centre between first and second epidemic waves (2020): a seroprevalence study in Catalonia, Spain

et al. 2022

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“… 16 In a study from Spain, seroprevalence among HCWs was 16.6% 17 and a longitudinal study in the United States showed a prevalence of 2.8% at baseline and 4.8% in a follow-up after six months. 18 During the first wave in Italy, 2.8% of HCWs tested seropositive. 19 Information about the community prevalence of anti-SARS-CoV-2 antibodies may be used as a gauge of community immunity before the introduction of vaccines.…”

Section: Discussionmentioning

confidence: 99%

A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia

Mushcab¹,

Al‐Tawfiq²,

Ghamdi³

et al. 2022

IDR

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Background The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2. Methods This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization’s risk factor assessment questionnaire. Results This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay. Conclusion Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH’s healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations. Clinicaltrials.gov Identifier NCT04469647.

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Section: Discussionmentioning

confidence: 99%

“…Two seroprevalence studies carried out at two major referral hospitals in Madrid reported that about 21% and 17% of their health care workers presented anti-SARS-CoV2 antibodies by May and June 2020, respectively ( 8 , 9 ). The Spanish Ministry of Health sponsored a national seroprevalence study reporting an overall prevalence of antibodies in Spain of 4.6% and in Madrid region in particular of 11.5% in May 2020 ( 10 ), confirming that, similarly to other studies, the infection was more prevalent between health care professionals than in the general population ( 9 , 11 , 12 ). However, this was not translated into a higher proportion of infected professionals in our department; our only positive result corresponded to a nurse that was initially working in the emergency department, who presented with symptoms and, after recovery, was transferred to our unit.…”

Section: Discussionmentioning

confidence: 99%

Application of a new protocol for providing obstetric care in an outpatient service during the COVID-19 pandemic in a public hospital in Madrid, Spain

et al. 2022

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ObjectiveTo evaluate the clinical implementation of a preventive COVID-19 protocol regarding re-organization of appointments and documented infections among health workers in an obstetric outpatient service.MethodsDescriptive analysis of the antenatal care at our obstetric outpatient service and infection rates among health care providers from March 19th to May 22nd, 2020. Appointments were divided into telephone calls or face-to-face examinations. A pre-consultation triage was implemented to identify suspected SARS-CoV2 infected women to reschedule them 14 days later or, if the consultation was non-delayable, to use complete Personal Protective Equipment (PPE). Firstly, the number of face-to-face appointments, telephone appointments, and COVID-19 diagnoses in pregnant women were analyzed. Secondly, the number of obstetricians and nurses diagnosed with SARS-CoV2 infection and their serologic status during universal screening in May 2020 were recorded.ResultsOne thousand eight hundred forty-two obstetric appointments were scheduled during this period, including 432 (23.5%) telephone appointments (96.53% according to clinical protocol, 1.62% symptomatic patients advised to stay at home, and 1.85% COVID-19 confirmed cases), and 1,410 (76.5%) face-to-face appointments (9.7% did not attend due to fear of getting the infection, 3.1% were lost-to-follow-up, 0.5% were rescheduled due to COVID-19 symptoms and 86.7% who did attend). Of the 1,223 women attending their hospital appointment, 3.6% screened positive at the triage (72.7% rescheduled and 27.3% seen with PPE). 43 rRT-PCR-SARS-CoV2 tests were performed, and two tested positive. No COVID-19 symptoms were reported among health workers at the outpatient obstetric service, and only one nurse presented immunoglobulin (Ig)G anti-SARS-CoV2.ConclusionA prompt implementation of a preventive protocol in a hospital obstetric outpatient service, including triage, hygienic and preventive measurements, and rescheduling pregnancy appointments, reduces the percentage of health workers affected by SARS-CoV2.

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SARS-COV-2 seroprevalence among all healthcare workers in a tertiary hospital in Spain

Cited by 6 publications

References 18 publications

COVID-19 among workers of a comprehensive cancer centre between first and second epidemic waves (2020): a seroprevalence study in Catalonia, Spain

COVID-19 among workers of a comprehensive cancer centre between first and second epidemic waves (2020): a seroprevalence study in Catalonia, Spain

A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia

Application of a new protocol for providing obstetric care in an outpatient service during the COVID-19 pandemic in a public hospital in Madrid, Spain

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