SARS-CoV-2 seroprevalence among health care workers in a New York City hospital: A cross-sectional analysis during the COVID-19 pandemic

Venugopal, Usha; Jilani, Nargis; Rabah, Sami; Shariff, Masood A.; Jawed, Muzamil; Batres, Astrid Mendez; Abubacker, Muhamed; Menon, Sharika Venugopal; Pillai, Anjana; Shabarek, Nehad; Kasubhai, Moiz; Dimitrov, Vihren; Menon, Vidya

doi:10.1016/j.ijid.2020.10.036

Cited by 108 publications

(135 citation statements)

References 16 publications

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“…Among healthcare workers, EMTs had a seroprevalence of 38.3% and the strongest association with seropositivity after adjustment. In contrast, other SARS-CoV-2 studies among NYC hospital-based healthcare workers found a seroprevalence ranging from 14% to 27% ( 15 , 16 ). EMS often occur in uncontrolled, unpredictable environments in which space is limited (e.g., ambulances) and require rapid decisions that might increase employee exposure risk.…”

Section: Discussionmentioning

confidence: 68%

Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May–July 2020

Sami¹,

Akinbami²,

Petersen³

et al. 2021

Emerg. Infect. Dis.

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We conducted a serologic survey in public service agencies in New York City, New York, USA, during May–July 2020 to determine prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among first responders. Of 22,647 participants, 22.5% tested positive for SARS-CoV-2–specific antibodies. Seroprevalence for police and firefighters was similar to overall seroprevalence; seroprevalence was highest in correctional staff (39.2%) and emergency medical technicians (38.3%) and lowest in laboratory technicians (10.1%) and medicolegal death investigators (10.8%). Adjusted analyses demonstrated association between seropositivity and exposure to SARS-CoV-2–positive household members (adjusted odds ratio [aOR] 3.52 [95% CI 3.19–3.87]), non-Hispanic Black race or ethnicity (aOR 1.50 [95% CI 1.33–1.68]), and severe obesity (aOR 1.31 [95% CI 1.05–1.65]). Consistent glove use (aOR 1.19 [95% CI 1.06–1.33]) increased likelihood of seropositivity; use of other personal protective equipment had no association. Infection control measures, including vaccination, should be prioritized for frontline workers.

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Section: Discussionmentioning

confidence: 68%

Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May–July 2020

Sami¹,

Akinbami²,

Petersen³

et al. 2021

Emerg. Infect. Dis.

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“… [81] China March Cross-Sectional ELISA 325 NA NA NA Low Venugopal et al. [82] USA March-May Cross Sectional Chemiluminescent Microparticle Immunoassay 478 41.5 68.8 13.6 High Vlachoyiannopoulos et al. [83] Greece April-May Cross Sectional ELISA 321 42.7 67.9 NA Low Xu et al.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of SARS-CoV-2 IgG antibodies among health care workers prior to vaccine administration in Europe, the USA and East Asia: A systematic review and meta-analysis

et al. 2021

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Background Knowing the seroprevalence of SARS-CoV-2 IgG antibodies across geographic regions before vaccine administration is one key piece of knowledge to achieve herd immunity. While people of all ages, occupations, and communities are at risk of getting infected with SARS-CoV-2, the health care workers (HCWs) are possibly at the highest risk. Most seroprevalence surveys with HCWs conducted worldwide have been limited to Europe, North America, and East Asia. We aimed to understand how the seroprevalence of SARS-CoV-2 IgG antibodies varied across these geographic regions among HCWs based on the available evidences. Methods By searching through PubMed, ScienceDirect, and Google Scholar databases, eligible studies published from January 1, 2020 to January 15, 2021 were included for the systematic review and meta-analysis. The random-effects model was used to estimate the pooled proportion of IgG seropositive HCWs. Publication bias was assessed by funnel plot and confirmed by Egger's test. Heterogeneity was quantified using I 2 statistics. We performed sensitivity analyses based on sample size, diagnostic method and publication status. The study protocol was registered with PROSPERO (CRD42020219086). Findings A total of 53 peer-reviewed articles were selected, including 173,353 HCWs (32.7% male) from the United States, ten European, and three East Asian countries. The overall seropositive prevalence rate of IgG antibodies was 8.6% in these regions (95% CI= 7.2–9.9%). Pooled seroprevalence of IgG antibodies was higher in studies conducted in the USA (12.4%, 95% CI= 7.8–17%) than in Europe (7.7%, 95% CI=6.3–9.2%) and East Asia (4.8%, 95% CI=2.9–6.7%). The subgroup study also estimated that male HCWs had 9.4% (95% CI= 7.2–11.6%) IgG seroconversion, and female HCWs had 7.8% (95% CI=5.9–9.7%). The study exhibits a high prevalence of IgG antibodies among HCWs under 40 years in the USA, conversely, it was high in older HCWs (≥40 years of age) in Europe and East Asia. In the months February-April 2020, the estimated pooled seroprevalence was 5.7% (4.0–7.4%) that increased to 8·2% (6.2–10%) in April-May and further to 9.9% (6.9–12.9%) in the May-September time-period. Interpretation In the view of all evidence to date, a significant variation in the prevalence of SARS-CoV-2 antibodies in HCWs is observed in regions of Europe, the United States, and East Asia. The patterns of IgG antibodies by time, age, and gender suggest noticeable regional differences in transmission of the virus. Based on the insights driven from the analysis, priority is required for effective vaccination for older HCWs from Europe and East Asia. A considerable high seroprevalence of IgG among HCWs from the USA suggests a high rate of past infection that indicates the need to take adequate measures to prevent hospital spread. Moreover, the seroprevalence trend was not substantially changed after May 2020, suggesting a slow ...

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“…The presence of serum antibodies specific to SARS-CoV-2, the virus that causes COVID-19, reflects prior exposure. Seroprevalence, or seropositivity, estimates range from 3-50% depending on the population surveyed, method of testing, and viral antigen target (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Most tests measure antibody content in blood or serum, which often necessitates contact with a health care facility.…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure

Demonbreun¹,

McDade²,

Pesce³

et al. 2021

JCI Insight

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SARS-CoV-2 seroprevalence among health care workers in a New York City hospital: A cross-sectional analysis during the COVID-19 pandemic

Cited by 108 publications

References 16 publications

Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May–July 2020

Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May–July 2020

Seroprevalence of SARS-CoV-2 IgG antibodies among health care workers prior to vaccine administration in Europe, the USA and East Asia: A systematic review and meta-analysis

Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure

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