SARS-CoV-2 serostatus of healthcare worker in the Austrian state Vorarlberg between June 2020 and January 2021

Atzl, Michele; Muendlein, Axel; Winder, Thomas; Fraunberger, Peter; Brandtner, Eva-Maria; Geiger, Kathrin; Klausberger, Miriam; Duerkop, Mark; Sprenger, Lukas; Mutschlechner, Beatrix; Volgger, Andreas; Benda, Magdalena; Severgnini, Luciano; Jaeger, Johannes B; Lang, Aloïs B.; Leiherer, Andreas

doi:10.1101/2021.02.19.21252045

Cited by 4 publications

(4 citation statements)

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“…Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, millions of people have been vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an attempt to curb mortality rates and to relieve the burden on hospitals. Various laboratory assays were developed to detect antibodies against SARS-CoV-2 [1][2][3][4]. However, it is currently unknown how high antibody levels in hospitalized patients need to be in order to provide protection against mortality.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality

Mink

List

Hoefle³

et al. 2023

J Intern Med

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Background Millions of people have now been vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, it is still unclear which antibody levels provide protection against mortality. It is further unknown whether measuring antibody concentrations on hospital admission allows for identifying patients with a high risk of mortality. Objectives To evaluate whether anti‐SARS‐CoV2‐spike antibodies on hospital admission predict in‐hospital mortality in patients with coronavirus disease 2019. Methods We conducted a prospective, multicentre cohort study on 1152 hospitalized patients who tested positive for SARS‐CoV‐2 with a polymerase chain reaction–based assay. Patients were classified by vaccination status. Anti‐SARS‐CoV‐2 spike antibodies were determined on hospital admission. The investigated end point was in‐hospital mortality for any cause. Results Spike antibodies on hospital admission were significantly lower in non‐survivors in both non‐vaccinated (73 U/ml, 95%CI 0–164 vs. 175 U/ml, 95%CI 124–235, p = 0.002) and vaccinated patients (1056 U/ml, 95%CI 701–1411 vs. 1668 U/ml, 95%CI 1580–1757, p < 0.001). Further, spike antibodies were significantly lower in fully vaccinated and boostered patients who died compared to those who survived (mean 883 U/ml, 95%CI 406–1359 vs. 1292 U/ml, 95%CI 1152–1431, p = 0.017 and 1485 U/ml, 95%CI 836–2133 vs. 2050 U/ml, 95%CI 1952–2149, p = 0.036). Patients infected with the currently prevailing Omicron variant were three times more likely to die if spike antibodies were <1200 U/ml (OR 3.458, 95%CI 1.562–7.656, p = 0.001). After adjusting for potential confounders, this value increased to an aOR of 4.079 (95%CI 1.809–9.198, p < 0.001). Conclusion Anti‐SARS‐CoV2 spike‐antibody levels on hospital admission are inversely associated with in‐hospital mortality. Hospitalized patients with lower antibody levels have a higher risk of mortality.

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Section: Introductionmentioning

confidence: 99%

Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality

Mink

List

Hoefle³

et al. 2023

J Intern Med

Self Cite

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“…The prevalence found (22.3%) is very similar to that reported in a study conducted in healthcare workers at a hospital in Santiago from April to July 2020 (24%) (19) and consistent with previous evidence in health personnel, whose seroprevalence is higher than what is observed in the community, demonstrating the high risk faced by these personnel. (33)(34)(35)(36)(37)(38) When controlling for potential confounding variables in our study, the medical profession increases the chance of disease. This finding is probably associated with the greater time that these professionals spend in PHC providing care to people with recent onset of the disease, when there is a greater risk of transmission.…”

Section: Discussionmentioning

confidence: 75%

Immune response against SARS-CoV-2 of primary healthcare personnel in a commune of Santiago, Chile: follow-up at 6 months

Matute¹,

Olea²,

Hirmas³

et al. 2022

JHS

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Background: The COVID-19 pandemic that emerged in Wuhan, China at the end of 2019, spread rapidly around the world with almost 600 million cases and 6.3 million deaths today. The most affected were health workers with at least three times the risk of contracting the disease than the general community. Most studies on seroprevalence in health workers focus on hospital care establishments and what happens in Primary Health Care (PHC) has not been investigated with the same intensity. Objectives: to determine the prevalence and know the variation of antibody titers for SARS-CoV-2 in serial samples of primary healthcare personnel from the commune of La Pintana. Method: an analytical observational study with a cross-sectional and a longitudinal component, carried out from November 2020 to June 2021. The first component consisted of an IgG antibody seroprevalence study performed at baseline (time 0) in volunteer of a universe of 900 workers. The longitudinal component considered the monitoring of IgG antibodies in those who presented a positive result at baseline and the analysis of neutralizing antibodies in a random sub-sample of 50% of them. Additionally, sociodemographic and clinical information was collected via a questionnaire. Univariate, bivariate, and longitudinal analyses were performed to evaluate differences in antibodies. The study was approved by the Universidad del Desarrollo's Scientific Ethics Committee. Results: 463 primary healthcare workers participated, mostly women and with a median of 38 years; doctors and nurses represented 9.5% each and 14.7% had a history of COVID-19. The seroprevalence at baseline was 22.3% and was associated with younger age, being a doctor and having been in close contact of a case. IgG titers increased with the vaccine, but decreased over time. At the 6-month follow-up, 76% had neutralizing antibodies. Those belonging to indigenous peoples had higher IgG levels and higher rates of neutralizing antibodies. Conclusion: Healthcare workers were highly affected by COVID-19, and the medical profession and younger age were factors associated with increased risk. Antibodies decrease over time, highlighting the importance of followup studies, as well as the importance of vaccination boosters in healthcare workers, especially those in PHC.

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Section: Discussionmentioning

confidence: 80%

Immune response against SARS-CoV-2 of primary healthcare personnel in a commune of Santiago, Chile: follow-up at 6 months

Normandin

Matute

Hirmas

et al. 2022

Preprint

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Background: The COVID-19 pandemic that emerged in Wuhan, China at the end of 2019, spread rapidly around the world with almost 600 million cases and 6.3 million deaths today. The most affected were health workers with at least three times the risk of contracting the disease than the general community. Most studies on seroprevalence in health workers focus on hospital care establishments and what happens in Primary Health Care (PHC) has not been investigated with the same intensity. Objectives: to determine the prevalence and know the variation of antibody titers for SARS-CoV-2 in serial samples of primary healthcare personnel from the commune of La Pintana. Method: an analytical observational study with a cross-sectional and a longitudinal component, carried out from November 2020 to June 2021. The first component consisted of an IgG antibody seroprevalence study performed at baseline (time 0) in volunteer of a universe of 900 workers. The longitudinal component considered the monitoring of IgG antibodies in those who presented a positive result at baseline and the analysis of neutralizing antibodies in a random sub-sample of 50% of them. Additionally, sociodemographic and clinical information was collected via a questionnaire. Univariate, bivariate, and longitudinal analyses were performed to evaluate differences in antibodies. The study was approved by the Universidad del Desarrollo's Scientific Ethics Committee. Results: 463 primary healthcare workers participated, mostly women and with a median of 38 years; doctors and nurses represented 9.5% each and 14.7% had a history of COVID-19. The seroprevalence at baseline was 22.3% and was associated with younger age, being a doctor and having been in close contact of a case. IgG titers increased with the vaccine, but decreased over time. At the 6-month follow-up, 76% had neutralizing antibodies. Those belonging to indigenous peoples had higher IgG levels and higher rates of neutralizing antibodies. Conclusion: Healthcare workers were highly affected by COVID-19, and the medical profession and younger age were factors associated with increased risk. Antibodies decrease over time, highlighting the importance of follow-up studies, as well as the importance of vaccination boosters in healthcare workers, especially those in PHC.

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SARS-CoV-2 serostatus of healthcare worker in the Austrian state Vorarlberg between June 2020 and January 2021

Cited by 4 publications

References 36 publications

Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality

Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality

Immune response against SARS-CoV-2 of primary healthcare personnel in a commune of Santiago, Chile: follow-up at 6 months

Immune response against SARS-CoV-2 of primary healthcare personnel in a commune of Santiago, Chile: follow-up at 6 months

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