SARS-CoV-2 strain wars continues: Chemical and thermodynamic characterization of live matter and biosynthesis of Omicron BN.1, CH.1.1 and XBC variants

Popovic, Marko

doi:10.1016/j.mran.2023.100260

Cited by 16 publications

(3 citation statements)

References 67 publications

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“…Gibbs energy of biosynthesis of the nucleocapsid of the BA.2.86 Pirola variant of SARS-CoV-2 is -221.75 kJ/C-mol (Table 4). Gibbs energies of biosynthesis of nucleocapsids of other variants under monitoring are -221.21 for the Omicron CH.1.1 variant [Popovic, 2023a] and -221.19 kJ/C-mol for the Omicron XBB.1.16 variant [Popovic et al, 2023a]. Therefore, Gibbs energies of biosynthesis of the BA.2.86, CH.1.1 and XBB.1.16 variants are very similar.…”

Section: Virus-host and Virus-virus Interactionsmentioning

confidence: 82%

“…Biosynthesis reactions are macrochemical equations of conversion of nutrients into new live matter in metabolism [Assael et al, 2022;von Stockar, 2013avon Stockar, , 2013bBattley, 2013Battley, , 1999b]. The general biosynthesis reaction for viruses has the form (Amino acid) + O2 + HPO4 2-+ HCO3 -→ (Bio) + SO4 2-+ H2O + H2CO3 (7) where (Amino acid) represents a mixture of amino acids, which has the empirical formula CH1.798O0.4831N0.2247S0.022472 [Popovic et al, 2023a[Popovic et al, , 2023bPopovic, 2023aPopovic, , 2023bPopovic, , 2022c. Newly synthetized live matter, (Bio), is represented with its empirical formula [Popovic et…”

Section: Biosynthesis Reactionsmentioning

confidence: 99%

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SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant

Popović,

Šekularac,

Popović

2023

Preprint

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Similarly to a phoenix, SARS-CoV-2 has appeared periodically in waves. The new variants that appeared through mutations have during the 4 years of the pandemic suppressed earlier variants, causing new waves of the pandemic. The Omicron BA.2.86 Pirola variant is the latest in the sequence of SARS-CoV-2 variants, which appeared in 2023. The BA.2.86 variant has started to spread rapidly and we are witnesses of a new epidemic wave. In this short period, an increased infectivity was noticed, which results in rapid spreading and decreased pathogenicity, which results in a lower number of severe cases. However, in the public there is a fear of further development of the epidemic. This analysis was made with the goal to assess the risks in the period of late 2023. Mutations that were developed by the BA.2.86 variant have led to a change in empirical formula and thermodynamic properties. It seems that there is no ground for fear of an extensive spreading of severe forms, but there are reasons for caution and monitoring of the spreading of the epidemic and potential appearance of new mutations.

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Section: Virus-host and Virus-virus Interactionsmentioning

confidence: 82%

Section: Biosynthesis Reactionsmentioning

confidence: 99%

SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant

Popović,

Šekularac,

Popović

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the greater spread of SARS-CoV-2 through the population and longer duration of the COVID-19 pandemic have led to a large number of mutations in the SARS-CoV-2 virus. The SARS-CoV-2 virus has mutated numerous times from the Hu-1 variant in 2019 to the newest Omicron BN.1, CH.1.1 and XBC variants [ 51 ]. Therefore, SARS-CoV-2 virus is from the evolutionary aspect one of the best characterized viruses, from the perspective of molecular biology, biochemistry and thermodynamics.…”

Section: Discussionmentioning

confidence: 99%

COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

Popovic

Martin

Head

2023

Heliyon

Self Cite

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Biothermodynamics of Hemoglobin and Red Blood Cells: Analysis of Structure and Evolution of Hemoglobin and Red Blood Cells, Based on Molecular and Empirical Formulas, Biosynthesis Reactions, and Thermodynamic Properties of Formation and Biosynthesis

Popović,

Stevanović,

Pantović Pavlović

2024

J Mol Evol

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SARS-CoV-2 strain wars continues: Chemical and thermodynamic characterization of live matter and biosynthesis of Omicron BN.1, CH.1.1 and XBC variants

Cited by 16 publications

References 67 publications

SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant

SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant

COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

Biothermodynamics of Hemoglobin and Red Blood Cells: Analysis of Structure and Evolution of Hemoglobin and Red Blood Cells, Based on Molecular and Empirical Formulas, Biosynthesis Reactions, and Thermodynamic Properties of Formation and Biosynthesis

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