SARS-COV-2 – the pandemic of the XXI century, clinical manifestations – neurological implications

Săceleanu, Vicențiu; Moreanu, Mihai-Stelian; Covache-Busuioc, Razvan-Adrian; Mohan, Aurel George; Ciurea, Alexandru Vlad

doi:10.25122/jml-2020-0151

Cited by 3 publications

(3 citation statements)

References 109 publications

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“…Genetics and genomics have become essential tools in combatting its spread. Geneticists have had a crucial role in fighting the COVID-19 pandemic by providing insights into the behavior of the virus, tracking its spread, developing diagnostic tests, and informing public health interventions [ 30 ].…”

Section: Establishing Dna As the Genetic Blueprint: Key Evidence And ...mentioning

confidence: 99%

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Celebrating 70 years of DNA discovery: exploring the Blueprint of Life

Glavan,

Ciurea,

Costin

et al. 2024

JMedLife

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Section: Establishing Dna As the Genetic Blueprint: Key Evidence And ...mentioning

confidence: 99%

“…These vaccines use the genetic information of virus particles to produce fragments that elicit protective immune responses against infection. Genomic surveillance-guided modifications were made to existing vaccines to keep up with emerging variants while maintaining effectiveness [ 30 ].…”

Section: Establishing Dna As the Genetic Blueprint: Key Evidence And ...mentioning

confidence: 99%

Celebrating 70 years of DNA discovery: exploring the Blueprint of Life

Glavan,

Ciurea,

Costin

et al. 2024

JMedLife

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“…In 2009, the first influenza A (H1N1) epidemic broke out in Mexico, affecting 208 countries [ 4 ]. In 2012, a second coronavirus pandemic broke out in the Arabian Peninsula—MERS [ 5 , 6 , 7 ]. In December 2019, another pandemic, and the third one caused by a human coronavirus, broke out in Wuhan, China [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Anxiety and Depression Levels and Coping Strategies among Polish Healthcare Workers during the COVID-19 Pandemic

Budzyńska

Moryś

2023

IJERPH

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During the COVID-19 pandemic, medical staff were commonly exposed to stress, work under pressure, and long shifts, and may have experienced a fear of infecting loved ones or a fear for their own health. All of these factors may have increased the likelihood that healthcare workers will experience the symptoms of depression, anxiety, or other mental health disorders. In this cross-sectional study, a group of respondents was gathered from the employees of 78 hospitals in Poland. A questionnaire was completed electronically by 282 people, aged between 20 and 78 years. The study used the Hospital Anxiety and Depression Scale (HADS) and the MiniCOPE questionnaire to examine anxiety and depression symptoms, and coping strategies, respectively. With age, the respondents declared fewer symptoms of anxiety and tended to have milder symptoms of depression. Participants with chronic illnesses, mood disorders, or anxiety disorders also reported higher levels of anxiety and depression symptoms. More than 20% of healthcare workers felt the need to consult with a psychologist. In the entire group of healthcare professionals surveyed, the most commonly used strategies for coping with stress were “denial”, “psychoactive drug and alcohol use”, and “cessation of activities”, while the least used strategy was “acceptance”. Given the most commonly used strategies in the surveyed group of healthcare professionals, they may be predictors for a deterioration in mental state in the long run. The obtained results also suggest that it is likely that pre-existing health problems had a greater impact on the mental health of medical staff during the COVID-19 pandemic than the profession itself. Therefore, taking care of the well-being and mental health of healthcare workers should be a priority for employers.

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The many facets of CD26/dipeptidyl peptidase 4 and its inhibitors in disorders of the CNS – a critical overview

Bernstein

Keilhoff

Dobrowolny

et al. 2022

Reviews in the Neurosciences

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Dipeptidyl peptidase 4 is a serine protease that cleaves X-proline or X-alanine in the penultimate position. Natural substrates of the enzyme are glucagon-like peptide-1, glucagon inhibiting peptide, glucagon, neuropeptide Y, secretin, substance P, pituitary adenylate cyclase-activating polypeptide, endorphins, endomorphins, brain natriuretic peptide, beta-melanocyte stimulating hormone and amyloid peptides as well as some cytokines and chemokines. The enzyme is involved in the maintenance of blood glucose homeostasis and regulation of the immune system. It is expressed in many organs including the brain. DPP4 activity may be effectively depressed by DPP4 inhibitors. Apart from enzyme activity, DPP4 acts as a cell surface (co)receptor, associates with adeosine deaminase, interacts with extracellular matrix, and controls cell migration and differentiation. This review aims at revealing the impact of DPP4 and DPP4 inhibitors for several brain diseases (virus infections affecting the brain, tumours of the CNS, neurological and psychiatric disorders). Special emphasis is given to a possible involvement of DPP4 expressed in the brain.While prominent contributions of extracerebral DPP4 are evident for a majority of diseases discussed herein; a possible role of “brain” DPP4 is restricted to brain cancers and Alzheimer disease. For a number of diseases (Covid-19 infection, type 2 diabetes, Alzheimer disease, vascular dementia, Parkinson disease, Huntington disease, multiple sclerosis, stroke, and epilepsy), use of DPP4 inhibitors has been shown to have a disease-mitigating effect. However, these beneficial effects should mostly be attributed to the depression of “peripheral” DPP4, since currently used DPP4 inhibitors are not able to pass through the intact blood–brain barrier.

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SARS-COV-2 – the pandemic of the XXI century, clinical manifestations – neurological implications

Cited by 3 publications

References 109 publications

Celebrating 70 years of DNA discovery: exploring the Blueprint of Life

Celebrating 70 years of DNA discovery: exploring the Blueprint of Life

Anxiety and Depression Levels and Coping Strategies among Polish Healthcare Workers during the COVID-19 Pandemic

The many facets of CD26/dipeptidyl peptidase 4 and its inhibitors in disorders of the CNS – a critical overview

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