SARS-CoV-2 Ultraviolet Radiation Dose-Response Behavior

Ernest, R. B.; Petri, Brian; Sun, Wei

doi:10.6028/jres.126.018

Cited by 12 publications

(10 citation statements)

References 42 publications

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“…The structure and composition of SARS-CoV-2 render it quite sensitive to exposure to UV-C radiation. , In aqueous suspensions, SARS-CoV-2 displays inactivation responses that are roughly first order with respect to the UV-C dose. The magnitude of the inactivation constant for SARS-CoV-2 is high relative to most other airborne pathogens.…”

Section: Methods: Quantitative Microbial Risk Assessment (Qmra) Devel...mentioning

confidence: 99%

Quantitative Microbial Risk Assessment for Quantification of the Effects of Ultraviolet Germicidal Irradiation on COVID-19 Transmission

Blatchley,

Cui

2023

Environ. Sci. Technol.

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Quantitative microbial risk assessment (QMRA) is presented as a tool for evaluation of the effectiveness of ultraviolet germicidal irradiation (UVGI) systems for the disinfection of indoor air. The QMRA is developed in the context of UVGI system implementation for control of SARS-CoV-2 infection and comprises submodels to address problem formulation, exposure assessment, and health effects assessment, all of which provide input to a risk characterization submodel. The model simulations indicate that UVGI systems can effectively control the risk of infection associated with SARS-CoV-2 for low to moderate virus emission rates. The risk of disease transmission is strongly influenced by the rate of pathogen emission by an infected individual, the output power of UVGI fixtures and their configuration, the source of UV-C radiation implemented in the UVGI fixtures, and the characteristics of the heating, ventilation, and air conditioning (HVAC) system. The QMRA framework provides a quantitative link between UVGI/HVAC system characteristics and changes in the risk of disease transmission. The framework can be adapted to other airborne pathogens and provides a rational basis for the design, testing, and validation of UVGI systems.

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Section: Methods: Quantitative Microbial Risk Assessment (Qmra) Devel...mentioning

confidence: 99%

Quantitative Microbial Risk Assessment for Quantification of the Effects of Ultraviolet Germicidal Irradiation on COVID-19 Transmission

Blatchley,

Cui

2023

Environ. Sci. Technol.

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“…These findings were based on previous research that demonstrated that SARs-CoV-1 and MS-2 bacteriophage displayed similar UV dose responses. There is limited data on acceptable surrogates for SARs-CoV-2 and the inactivation of SARs-CoV-1 and SARs-Cov-2 were expected to be similar, as they are both nonsegmented, enveloped, single-stranded, RNA viruses ( 15 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of UV-C Disinfection on N95 and KN95 Filtering Facepiece Respirator Reuse

Bernardy

Elardo

Trautz

et al. 2022

Appl Environ Microbiol

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“…Among various disinfection procedures recommended by the CDC guidelines, six disinfection methods were chosen that can be readily deployed: ultraviolet (UV) radiation, dry heat treatment, steam treatment, alcohol, chlorine compounds, and quaternary ammonium compounds . The conditions of each disinfection method were set in a way to ensure that SARS-CoV-2 was efficiently inactivated by surface disinfection procedures: (1) UV sterilizer cabinet for 15 min, , (2) dry heat treatment at 85 °C for 30 min, , (3) steam at 100 °C for 10 min, (4) commercial-grade 75% alcohol spray (Purple Frog Products, Canada), , (5) 2% household bleach solution spray (Clorox, U.S.A.), and (6) quaternary ammonium compounds (0.15% benzalkonium chloride/0.15% alkyl ethyl benzyl ammonium chloride) spray (Lloyds Laboratories, Inc., Canada) as shown in Scheme . Each of these methods was employed for 10 and 20 cycles.…”

Section: Methodsmentioning

confidence: 99%

Can Medical-Grade Gloves Provide Protection after Repeated Disinfection?

Esmizadeh

Chang

Jubinville

et al. 2020

ACS Appl. Polym. Mater.

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The advent of the COVID-19 pandemic has generated an increased consumption of personal protective equipment (PPE), including gloves and masks, by healthcare workers and by the general public at a global scale. This has generated substantial shortage of these single-use and disposable PPEs that will end up as a landfill waste. Extending the life cycle of PPEs, such as gloves, by disinfecting treatments could help mitigate these concerns. However, the effect of various disinfection treatments on the functionality of gloves is unknown. In this study, six commonly used viral disinfection treatment methods (i.e., ultraviolet (UV) radiation, dry heat, steam, alcohol, chlorine compounds, and quaternary ammonium compounds) were evaluated for their effect on the performance attributes of two commonly used medical-grade gloves and nitrile and vinyl (latex) gloves. The barrier properties of both gloves against water and ethanol vapor flux were not affected up to 10 cycles of disinfection cycles. However, the increase in the disinfection cycle from 10 to 20 slightly reduced their barrier properties with minor variation in the type of disinfection and glove type. Infrared spectroscopy and microscopy investigations confirmed that both types of gloves could withstand up to 20 cycles of disinfection treatments with no observable change in the chemical structure and surface morphology of the disinfected surfaces, respectively. Lastly, tear property testing of the gloves indicated little to no change from the baseline after 20 cycles of treatment in both the nitrile and vinyl-based gloves. Overall, this study indicated that alcohol, UV, and heat treatment could be acceptable disinfection methods that allow the reuse of gloves up to 20 cycles. Such repeated disinfection of gloves not only reduces the strain on the supply of gloves but also decreases the postconsumer landfilled waste and environmental footprint of gloves.

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SARS-CoV-2 Ultraviolet Radiation Dose-Response Behavior

Cited by 12 publications

References 42 publications

Quantitative Microbial Risk Assessment for Quantification of the Effects of Ultraviolet Germicidal Irradiation on COVID-19 Transmission

Quantitative Microbial Risk Assessment for Quantification of the Effects of Ultraviolet Germicidal Irradiation on COVID-19 Transmission

Effects of UV-C Disinfection on N95 and KN95 Filtering Facepiece Respirator Reuse

Can Medical-Grade Gloves Provide Protection after Repeated Disinfection?

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