SARS-CoV-2 vaccine-associated-tinnitus: A review

Ahmed, Syed Hassan; Waseem, Summaiyya; Shaikh, Taha Gul; Qadir, Nashwa Abdul; Siddiqui, Sarush Ahmed; Ullah, Irfan; Waris, Abdul; Yousaf, Zohaib

doi:10.1016/j.amsu.2022.103293

Cited by 21 publications

(29 citation statements)

References 56 publications

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“…Reports of sudden sensorineural hearing loss (SSNHL) and tinnitus following COVID-19 vaccination have raised the question whether the eighth cranial nerve and/or the inner ear might also be affected by processes following COVID-19 vaccination. Possible pathomechanisms discussed in this context comprise autoimmune cross-reactivity between pathogen and host proteins, deposition of immune complexes in the inner ear and reactivation of herpes simplex virus (HSV) or varizella zoster virus (VZV) in the ganglia of the eighth cranial nerve (9,10).…”

Section: Introductionmentioning

confidence: 99%

Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center

et al. 2022

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ObjectiveThe aim of the present study was to identify patients who developed acute unilateral peripheral vestibulopathy (AUPVP) after COVID-19 vaccination.MethodsFor this single-center, retrospective study, we screened the medical records of our tertiary interdisciplinary neurotology center for patients who had presented with AUPVP within 30 days after COVID-19 vaccination (study period: 1 June−31 December 2021). The initial diagnosis of AUPVP was based on a comprehensive bedside neurotological examination. Laboratory vestibular testing (video head impulse test, cervical and ocular vestibular evoked myogenic potentials, dynamic visual acuity, subjective visual vertical, video-oculography, caloric testing) was performed 1–5 months later.ResultsTwenty-six patients were diagnosed with AUPVP within the study period. Of those, n = 8 (31%) had developed acute vestibular symptoms within 30 days after COVID-19 vaccination (mean interval: 11.9 days, SD: 4.8, range: 6–20) and were thus included in the study. The mean age of the patients (two females, six males) was 46 years (SD: 11.7). Seven patients had received the Moderna mRNA vaccine and one the Pfizer/BioNTech mRNA vaccine. All patients displayed a horizontal(-torsional) spontaneous nystagmus toward the unaffected ear and a pathological clinical head impulse test toward the affected ear on initial clinical examination. Receptor-specific laboratory vestibular testing performed 1–5 months later revealed recovery of vestibular function in two patients, and heterogeneous lesion patterns of vestibular endorgans in the remaining six patients.Discussion and ConclusionsThe present study should raise clinicians' awareness for AUPVP after COVID-19 vaccination. The relatively high fraction of such cases among our AUPVP patients may be due to a certain selection bias at a tertiary neurotology center. Patients presenting with acute vestibular symptoms should be questioned about their vaccination status and the date of the last vaccination dose. Furthermore, cases of AUPVP occurring shortly after a COVID-19 vaccination should be reported to the health authorities to help determining a possible causal relationship.

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Section: Introductionmentioning

confidence: 99%

Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center

et al. 2022

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“…Additionally, it could be related to an anxiety-related immunization reaction, as anxiety has been linked to severe/persistent tinnitus, while it cannot be excluded that an autoimmune inner ear condition or a coincidental event could also have occurred [ 132 ]. Tinnitus has rarely been reported after hepatitis B vaccination, and, also, anti-spike antibodies may react with antigens everywhere along the auditory pathway, causing inflammation in the tympanic membrane, ossicular chain, cochlea, cochlear arteries, organ of Corti and other parts of the auditory system [ 133 ].…”

Section: Mrna Vaccination Against Covid-19 and Diagnosis Of Spontaneo...mentioning

confidence: 99%

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

Mouliou

Dardiotis

2022

Diagnostics

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The novel mRNA vaccinations against COVID-19 are gaining worldwide attention for their efficacy, as well as the diagnosis of some post-vaccination-reported adverse reactions. In this state-of-the-art review article, we present the current evidence regarding mainly the diagnosis of spontaneous allergic reactions, the skin occurrences, the vascular, blood, endocrine and heart events, the respiratory reports, the gastrointestinal, hepatic and kidney events, the reproductive and pregnancy issues and the muscle events, as well as the ear, eye, neurologic and psychiatric events following mRNA vaccination against COVID-19. We further present some evidence regarding the mRNA strategies and we discuss our expert opinion on the knowns and the unknowns towards the topic.

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“…However, the COVID-19 vaccine-associated tinnitus, although not a severe adverse event, had attracted the clinicians’ attention gradually. 1 Although it had not been well studied, the vaccination-mediated immune reaction was considered to be one of the major reasons of this adverse event. Therefore, the immune-targeted treatment, such as steroid, was considered to be an effective treatment.…”

Section: Case Reportmentioning

confidence: 99%

“… 2 However, not every patient with COVID-19-associated tinnitus responded well to the steroid treatment. 1 In this case report, we present a case with exacerbated tinnitus after her second dosage Pfizer–BioNTech COVID-19 vaccination, who responded well to the repetitive transcranial magnetic stimulation (rTMS) treatment.…”

Section: Case Reportmentioning

confidence: 99%

Pfizer–BioNTech COVID-19 vaccine-associated tinnitus and treatment with transcranial magnetic stimulation

Chen

Zeng

Lui

et al. 2022

QJM: An International Journal of Medicine

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The COVID-19 vaccine associated tinnitus had become well recognized after its development and widely usage. However, few knowledge about the management to relieve its severity had been few discussed. In the current case report, we present a case who suffered from worsening tinnitus after the second dosage of Pfizer–BioNTech COVID-19 vaccination. The pure tone audiometry (PTA) revealed hearing impairment after this vaccination with increased scores of tinnitus handicap index (THI). This tinnitus respond poorly to the low dosage steroid treatment. After the repetitive transcranial magnetic stimulation (rTMS) treatment, the followed PTA was improved, along with the reduced THI scores. The current report provided a point of view that the anti-inflammatory effect by rTMS might be considered to be an alternative choice to manage COVID-19 vaccine associated tinnitus. Furthermore, in consideration of benefit and this minor and reversible adverse event, we still strongly recommend the continuation of the administration of the Pfizer–BioNTech COVID-19 vaccine.

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SARS-CoV-2 vaccine-associated-tinnitus: A review

Cited by 21 publications

References 56 publications

Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center

Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

Pfizer–BioNTech COVID-19 vaccine-associated tinnitus and treatment with transcranial magnetic stimulation

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