SARS-CoV-2 Viral Load Predicts Mortality in Patients with and Without Cancer Who are Hospitalized with Coronavirus Disease 2019

Lf, Westblade; Brar, Gagan; Pinheiro, Laura C.; Paidoussis, Demetrios; Rajan, Mangala; Martín, Patricia Martínez; Goyal, Parag; Jl, Sepulveda; Zhang, L; George, Githin Benoy; D, Liu; Whittier, Susan; Plate, Markus; Cb, Small; Mm, Cushing; Tj, Walsh; Cooke, Jennifer; Safford, Monika M.; Loda, Massimo; Mj, Satlin

doi:10.2139/ssrn.3684128

Cited by 3 publications

(2 citation statements)

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“…Cancer patients have weak immune systems due to chemotherapy and corticosteroid therapy. Therefore, SARS Covirus-2 can easily infect these patients (8,9). Consequently, more precautions should be taken when hospitalizing patients for chemotherapy and continuing nursing care even at home.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Self-efficacy and Risk Perception of COVID-19 Among Cancer Patients Admitted to a Hospital in Ardabil-Iran

Matin¹,

Hosseini²,

Zarehoseinzade³

et al. 2023

Iran J Psychiatry Behav Sci

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Background: Cancer patients have defects in their immune systems due to chemotherapy and corticosteroid therapy and are at risk of viral diseases. Objectives: This study aimed to evaluate the risk perception and self-efficacy related to COVID-19 among cancer patients in Ardabil, Iran. Methods: This cross-sectional study was conducted on 200 cancer patients hospitalized in the oncology department of Ardabil Imam Khomeini Hospital in the summer of 2020, who were selected by simple random sampling. After obtaining informed consent, data was gathered using a questionnaire based on the extended parallel process model (EPPM) consisting of seven subscales, including perceived sensitivity, perceived severity, response efficacy, self-efficacy, intention, fear, and defensive motivation. The data were analyzed using linear regression by SPSS 18 and Stata 8. Results: Mean age of 200 cancer patients in this study was 52.35 ± 6.30 years. Among the constructs of EPPM, perceived susceptibility (coefficient = 0.23, P-value < 0.001) and perceived severity (coefficient = 0.160, P-value = 0.026) were significant predictors of self-efficacy, while response efficacy, intention, fear, and defensive motivation were not significant. In the regression model, R squared (R2) and adjusted R squared (adj-R2) were 0.182 and 0.180, respectively. Conclusions: This study demonstrated that perceived susceptibility and severity had significant roles in predicting self-efficacy. Therefore, it is proposed that according to the conditions of the cancer patients, health providers in oncology wards should provide the necessary information to enhance the risk perception regarding COVID-19 and promote self-efficacy to observe health protocols.

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Section: Introductionmentioning

confidence: 99%

Assessing the Self-efficacy and Risk Perception of COVID-19 Among Cancer Patients Admitted to a Hospital in Ardabil-Iran

Matin¹,

Hosseini²,

Zarehoseinzade³

et al. 2023

Iran J Psychiatry Behav Sci

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“…Despite current assays in the United States receiving Emergency Use Authorization as qualitative tests, the US Food and Drug Administration has uniquely allowed reporting of Ct values while simultaneously warning against their possible misinterpretation as a quantitative measure of viral load (1). The Ct values have been variously used by clinicians and in public health to guide treatment, monitor disease progression, assess prognosis, and inform isolation practices (2)(3)(4)(5)(6)(7)(8)(9). However, Ct values are known to vary between platforms and assays for any given quantity of virus, therefore, generating debate about their use (8,10).…”

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confidence: 99%

A Multi-Institutional Study Benchmarking Cycle Threshold Values for Major Clinical SARS-CoV-2 RT-PCR Assays

Cheng¹,

Cleveland

Degli-Angeli

et al. 2022

Preprint

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Real-time, reverse transcriptase PCR assays are a pervasive technology used for diagnosis of SARS-CoV-2 infection. These assays produce a cycle threshold value (Ct) corresponding to the first amplification cycle in which reliable amplification is detected. Such Ct values have been used by clinicians and in public health settings to guide treatment, monitor disease progression, assess prognosis, and inform isolation practices. To understanding the risk of reporting out uncalibrated Ct values and potential for instead reporting out calibrated viral load values, we performed a multi-institutional study to benchmark major clinical platforms against a calibrated standard. We found that for any given Ct value, corresponding viral loads varied up to 1000-fold among the different tests. In contrast, when these different assays were calibrated against a common standard and then used to test unknown de-identified specimens at several dilutions, viral load values showed high precision between methods (standard deviation and range of 0.36 and 1.1 log10 genome copies) and high accuracy compared with droplet digital PCR (ddPCR) determinations (difference between mean CDC N2 and Sarbeco E ddPCR determinations and mean determinations by calibrated RT-PCR assays examined in our study of 0.044 log10 genome copies). We, therefore, find strong support for calibration of SARS-CoV-2 RT-PCR tests to allow conversion of cycle thresholds to accurate and precise viral load values that are reproducible across major clinical systems. Implementation of calibrated assays will provide more reliable information for clinical decision making and allow more rigorous interpretation of SARS-CoV-2 laboratory data in clinical and laboratory investigation.

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Diagnostic SARS-CoV-2 Cycle Threshold Value Predicts Disease Severity, Survival, and Six-Month Sequelae in COVID-19 Symptomatic Patients

Trunfio

Venuti

Alladio

et al. 2021

Viruses

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To date, there is no severe acute respiratory syndrome coronavirus 2- (SARS-CoV-2)-specific prognostic biomarker available. We assessed whether SARS-CoV-2 cycle threshold (Ct) value at diagnosis could predict novel CoronaVirus Disease 2019 (COVID-19) severity, clinical manifestations, and six-month sequelae. Hospitalized and outpatient cases were randomly sampled from the diagnoses of March 2020 and data collected at 6 months by interview and from the regional database for COVID-19 emergency. Patients were stratified according to their RNA-dependent-RNA-polymerase Ct in the nasopharyngeal swab at diagnosis as follows: Group A ≤20.0, 20.0< group B ≤28.0, and Group C >28.0. Disease severity was classified according to a composite scale evaluating hospital admission, worst oxygen support required, and survival. Two hundred patients were included, 27.5% in Groups A and B both, 45.0% in Group C; 90% of patients were symptomatic and 63.7% were hospitalized. The median time from COVID-19 onset to swab collection was five days. Lethality, disease severity, type, and number of signs and symptoms, as well as six-month sequelae distributed inversely among the groups with respect to SARS-CoV-2 Ct. After controlling for confounding, SARS-CoV-2 Ct at diagnosis was still associated with COVID-19-related death (p = 0.023), disease severity (p = 0.023), number of signs and symptoms (p < 0.01), and presence of six-month sequelae (p < 0.01). Early quantification of SARS-CoV-2 may be a useful predictive marker to inform differential strategies of clinical management and resource allocation.

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SARS-CoV-2 Viral Load Predicts Mortality in Patients with and Without Cancer Who are Hospitalized with Coronavirus Disease 2019

Cited by 3 publications

References 0 publications

Assessing the Self-efficacy and Risk Perception of COVID-19 Among Cancer Patients Admitted to a Hospital in Ardabil-Iran

Assessing the Self-efficacy and Risk Perception of COVID-19 Among Cancer Patients Admitted to a Hospital in Ardabil-Iran

A Multi-Institutional Study Benchmarking Cycle Threshold Values for Major Clinical SARS-CoV-2 RT-PCR Assays

Diagnostic SARS-CoV-2 Cycle Threshold Value Predicts Disease Severity, Survival, and Six-Month Sequelae in COVID-19 Symptomatic Patients

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