SARS-CoV Antibody Prevalence in All Hong Kong Patient Contacts

Leung, GM; Chung, PH; Tsang, Thomas; Lim, Wilina; Chan, SK; Chau, Patsy; Donnelly, Christl A.; Ghani, Azra C.; Fraser, Christophe; Riley, Steven; Ferguson, Neil M.; Anderson, Roy M.; Law, YL; Mok, Thomas; Ng, T; Fu, Aisi; Leung, PY; Peiris, J S Malik; Lam, TH; Hedley, AJ

doi:10.3201/eid1009.040155

Cited by 76 publications

(69 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study on SARS-coronavirus seroprevalence in close contacts of all SARS patients in Hong Kong, only 2 (0.19%) were seropositive, and one of them was a 4-year-old boy who lived with his parents and grandfather, who all had SARS. 15 In fact, when restricted to close contacts of SARS cases from AMOY, the seroprevalence in that study was 1 of 161 (0.62%), which was virtually identical to our present estimate (P ϭ .99). Although symptoms of SARS in children were more nonspecific, a majority of patients could be reliably identified by vigilant frontline health care professionals according to stringent diagnostic criteria for case definition.…”

Section: Discussionsupporting

confidence: 86%

Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong

Lee¹,

Wong²,

Leung

et al. 2006

Pediatrics

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 86%

Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong

Lee¹,

Wong²,

Leung

et al. 2006

Pediatrics

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, only 260 cases had sufficient DNA left over for further analysis. The third control group of 309 HHC subjects was recontacted from the study of Leung et al [2]. These consisted of asymptomatic close contact of patients with SARS who were serologically negative for SARS.…”

Section: Resultsmentioning

confidence: 99%

“…A proportion of persons exposed to the virus without adequate protection, however, did not develop the disease [2]. It has been reported that of the close contacts of all 1755 patients with SARS diagnosed and treated in Hong Kong, only 14% actually died of the disease; the reason for this has yet to be discovered.…”

Section: Genetic Polymorphisms Have Been Demonstrated To Be Associatementioning

confidence: 94%

Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome

Chan

Ching

et al. 2007

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.

show abstract

“…Quarantine involves the segregation of healthy contacts and it was the policy for severe acute respiratory syndrome (SARS) in many countries. Such a drastic measure for SARS was carried out for the sake of caution, but the present evidence does not support the need for quarantine because subclinical infection is shown to be almost nonexistent [16] and even mildly symptomatic cases have not been reported [17].…”

Section: General Measures Within Healthcare Settingsmentioning

confidence: 71%

Infection prevention and control measures for acute respiratory infections in healthcare settings: an update

Seto¹,

Conly²,

Pessoa-Silva³

et al. 2013

East Mediterr Health J

View full text Add to dashboard Cite

Viruses account for the majority of the acute respiratory tract infections (ARIs) globally with a mortality exceeding 4 million deaths per year. The most commonly encountered viruses, in order of frequency, include influenza, respiratory syncytial virus, parainfluenza and adenovirus. Current evidence suggests that the major mode of transmission of ARIs is through large droplets, but transmission through contact (including hand contamination with subsequent selfinoculation) and infectious respiratory aerosols of various sizes and at short range (coined as "opportunistic" airborne transmission) may also occur for some pathogens. Opportunistic airborne transmission may occur when conducting highrisk aerosol generating procedures and airborne precautions will be required in this setting. General infection control measures effective for all respiratory viral infections are reviewed and followed by discussion on some of the common viruses, including severe acute respiratory syndrome (SARS) coronavirus and the recently discovered novel coronavirus. RÉSUMÉ Les virus sont responsables de la majorité des infections des voies respiratoires aiguës dans le monde avec une mortalité supérieure à quatre millions de décès par an. Les virus les plus fréquents sont, par ordre décroissant, celui de la grippe, le virus respiratoire syncytial, le virus paragrippal et l'adénovirus. Les données actuellement disponibles laissent penser que les grosses gouttelettes constituent le principal mode de transmission des infections des voies respiratoires aiguës, mais que la transmission par le contact (notamment la contamination par les mains suivie par une auto-inoculation) et par des aérosols respiratoires infectieux de différentes tailles et de courte portée (appelées transmissions par voie aérienne « opportunistes ») peut aussi se produire pour certains agents pathogènes. Une transmission par voie aérienne opportuniste peut survenir lors de l'utilisation de procédures générant des aérosols impliquant un risque élevé. Dans ce cas, des précautions contre une transmission aérienne sont requises. Des mesures de lutte anti-infectieuses générales efficaces contre toutes les infections respiratoires virales font l'objet d'un examen puis de discussions concernant certains virus courants, notamment le coronavirus du syndrome respiratoire aigu sévère et le nouveau coronavirus découvert récemment. ‫للمعلومات‬ ‫حتديث‬ ‫الصحية

show abstract

SARS-CoV Antibody Prevalence in All Hong Kong Patient Contacts

Cited by 76 publications

References 6 publications

Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong

Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong

Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome

Infection prevention and control measures for acute respiratory infections in healthcare settings: an update

Contact Info

Product

Resources

About