Sat-126 Progression of Renal Microvascular Abnormalities and the Effect of Sirolimus on Angiogenesis in Experimental Polycystic Kidney Disease

Abstract

Introduction: Acute Ischemic Stroke (AIS) is one of the leading cause of death, premature death, and disability globally. Hemorrhagic transformation (HT) is a common complication of AIS and is related to higher mortality, early neurological deterioration, and worse long-term functional outcome. Numerous observational studies have been published but the relationship between low eGFR level and HT in AIS patients is still controversial. We sought to do a meta-analysis to determine the association between low eGFR level and HT in AIS. Methods: We searched multiple electronic databases to identify studies published from 1990 to 2018. Following the application of inclusion and exclusion criteria, the ORs and 95% CIs of all the included studies were employed to estimate the pooled OR and 95% CI using the inverse variance random-effects method. Publication bias was assessed through Egger's test and Begg test. Heterogeneity was assessed by means of the I-squared value. Results: Ten observational studies including 4,653 AIS patients contributed to the analysis. Low eGFR level significantly increased the risk of HT in AIS patients (OR=1.60, 95% CI: 1.21-2.1, P = 0.001). Significant heterogeneity was seen among studies (I 2 = 45%, p = 0.06). No evidence of publication bias was observed in this meta-analysis. The effect size was stable during sensitivity analysis. We found no subgroup difference based on study design, study population, AIS type, stroke treatment, and study site.