SAT-TAVI (single antiplatelet therapy for TAVI) study: A pilot randomized study comparing double to single antiplatelet therapy for transcatheter aortic valve implantation

Antithrombotic treatment following transcatheter valve replacement: current considerations

“…Similar to the previous mentioned studies (11)(12)(13), the mortality and thromboembolic event rates demonstrated no difference between single and dual antiplatelet treated groups. In accordance with SAT-TAVI trial, overall vascular complications were significantly reduced in single (11) Durand (14) SAT-TAVI (12) Poliacikova (15) Ussia ( (11) Durand (14) SAT-TAVI (12) Poliacikova (15) Ussia ( , in naive patients aspirin alone (75 mg) was initiated the day before TAVI and followed lifelong.…”

“…The rationale of DAPT in TAVI patients consists in the ischemic event prevention, especially stroke, periprocedurally as well as in the first month post the procedure. The ARTE, SAT-TAVI and Ussia et al randomized trials demonstrated the lack of any beneficial impact of DAPT (aspirin and clopidogrel) on the stroke prevention post TAVR (11)(12)(13). Interestingly, ARTE trial (11) randomized 222 patients to aspirin versus aspirin plus clopidogrel following TAVR and revealed no significant difference in the 30-and 90-day stroke rate (0.9% versus 2.7% in aspirin versus DAPT groups), except a general tendency toward a lower incidence of mortality, myocardial infarction and stroke of aspirin alone, as described in Table 3.…”

Antithrombotic Regimens in Patients Undergoing Transcatheter Aortic Valve Implantation

“…This is consistent with the results from SAT-TAVI, a single-center randomized trial of 142 patients, showing a trend toward major and minor bleeding reductions with SAPT. 13 Moreover, the results of the present study showed equal valve function between the SAPT and DAPT treatment groups.…”

Single versus Dual Antiplatelet Therapy after Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis

“…Of the 7 included articles, 3 were RCTs[25-27] and the others were observational articles[16, 22-24]. The mean age was 82.1 years, and 55.6% of the patients were women.…”