SAT0005 Factors influencing fatigue and impact of fatigue on quality of life in ankylosing spondylitis (as) patients

Abstract

In the spondylarthropathy group, the laboratory variables were: HLA B27, HLA DR, DQ, anti ENA, serology CMV, EBV, HIV, hepatitis B, C. Results In 17/62 SpA patients (11 uSpA,5 AS,1 PA,17 females,1 male) Sjögren's syndrome diagnosis by the european criteria indicated a frequency of 27,4%. Of 62 SpA,12 were ANA positive (19,3%), of whom 5 had Sjögren's syndrome. ANA were detected in 8/17(47%) patients with Sjögren's syndrome. Of 62 SpA,20 had sicca symptoms (32,2%), compared to 3 of 102 (2,9%) controls. HLA B27 is positive in 12/17 patients (70,5%). The results of HLA DR, DQ seems to show an high frequency of HLA DR4, and DQ3 in the association group but the results are not significative. Conclusion The frequency of Sjögren's syndrome is 27,4%in the spondylartropathy group, thus more than in controls. Thus, the association seems to be not fortuitous. And it's interesting to see more females in a group with more undifferentiated spondylarthropathy: 16/17 are females.