Sat0549 sarcopenia in Rheumatoid Arthritis Female Patients: Relationship Between Whole Body and Trabecular Bone Score

Casabella, Andrea; Ruaro, Barbara; Seriolo, C.; Molfetta, Luigi; Alessandri, Elisa; Pizzorni, Carmen; Sulli, Alberto; Cutolo, Maurizio; Paolino, Sabrina

doi:10.1136/annrheumdis-2019-eular.5425

Cited by 2 publications

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“…We found ten cross-sectional studies ( n = 40–457 RA patients) that specifically sought to evaluate the prevalence of sarcopenia in established RA. 70–79…”

Section: Alterations In Body Composition In Rheumatoid Arthritismentioning

confidence: 99%

“…We found ten cross-sectional studies (n = 40-457 RA patients) that specifically sought to evaluate the prevalence of sarcopenia in established RA. [70][71][72][73][74][75][76][77][78][79] Although sarcopenia seems to be more frequent in RA patients compared with controls, 15,16,63,64,66 it is difficult to provide conclusive evidence since the studies used different definitions for sarcopenia and involved different populations. In a cross-sectional study of 123 Moroccan RA patients (women: 87%; mean disease duration: 9.8 years; patients receiving csDMARDs: 90.2%; patients receiving bDMARDs: 8.1%), 70 the prevalence of sarcopenia was reported to be 39.8% (using the criteria proposed by Baumgartner et al 48 ), but muscle strength and physical performance were not evaluated.…”

Section: Sarcopenia In Patients With Ramentioning

confidence: 99%

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Body composition in patients with rheumatoid arthritis: a narrative literature review

Letarouilly

Flipo

Cortet

et al. 2021

Therapeutic Advances in Musculoskeletal

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There is growing interest in the alterations in body composition (BC) that accompany rheumatoid arthritis (RA). The purpose of this review is to (i) investigate how BC is currently measured in RA patients, (ii) describe alterations in body composition in RA patients and (iii) evaluate the effect on nutrition, physical training, and treatments; that is, corticosteroids and biologic Disease Modifying Anti-Rheumatic Disease (bDMARDs), on BC in RA patients. The primary-source literature for this review was acquired using PubMed, Scopus and Cochrane database searches for articles published up to March 2021. The Medical Subject Headings (MeSH) terms used were ‘Arthritis, Rheumatoid’, ‘body composition’, ‘sarcopenia’, ‘obesity’, ‘cachexia’, ‘Absorptiometry, Photon’ and ‘Electric Impedance’. The titles and abstracts of all articles were reviewed for relevant subjects. Whole-BC measurements were usually performed using dual energy x-ray absorptiometry (DXA) to quantify lean- and fat-mass parameters. In RA patients, lean mass is lower and adiposity is higher than in healthy controls, both in men and women. The prevalence of abnormal BC conditions such as overfat, sarcopenia and sarcopenic obesity is significantly higher in RA patients than in healthy controls; these alterations in BC are observed even at an early stage of the disease. Data on the effect treatments on BC in RA patients are scarce. In the few studies published, (a) creatine supplementation and progressive resistance training induce a slight and temporary increase in lean mass, (b) exposure to corticosteroids induces a gain in fat mass and (c) tumour necrosis factor alpha (TNFα) inhibitors might be associated with a gain in fat mass, while tocilizumab might be associated with a gain in lean mass. The available data clearly demonstrate that alterations in BC occur in RA patients, but data on the effect of treatments, especially bDMARDs, are inconsistent and further studies are needed in this area.

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“…We found ten cross-sectional studies ( n = 40–457 RA patients) that specifically sought to evaluate the prevalence of sarcopenia in established RA. 70–79…”

Section: Alterations In Body Composition In Rheumatoid Arthritismentioning

confidence: 99%

Section: Sarcopenia In Patients With Ramentioning

confidence: 99%

Body composition in patients with rheumatoid arthritis: a narrative literature review

Letarouilly

Flipo

Cortet

et al. 2021

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

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What Role Does Trabecular Bone Score Play in Chronic Inflammatory Rheumatic Diseases?

Ruaro¹,

Casabella

Molfetta

et al. 2020

Front. Med.

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Patients suffering from rheumatic inflammatory diseases, e.g., systemic sclerosis, rheumatoid arthritis, and ankylosing spondylitis, are at risk of low bone mass. Dual-energy X-ray Absorptiometry (DXA) is the traditional radiological measurement technique for bone mineral density (BMD). The recently developed trabecular bone score (TBS) enhances the skeletal information provided by standard BMD. It re-analyzes the spatial dynamics of pixel intensity changes in lumbar spine DXA images, defining a quantitative index, characterizing trabecular bone microarchitecture. It has been demonstrated that low TBS values are associated with an increased incidence of fractures in patients with rheumatic diseases. These methods used together for bone damage evaluation can be of value to identify individuals who will potentially fracture. The main scientific literature on the clinical aspects of osteoporosis, including the use of TBS in evaluating this pathology, are herein reported aimed at shedding light on the role trabecular bone score plays in chronic inflammatory rheumatic diseases.

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Sat0549 sarcopenia in Rheumatoid Arthritis Female Patients: Relationship Between Whole Body and Trabecular Bone Score

Cited by 2 publications

References 0 publications

Body composition in patients with rheumatoid arthritis: a narrative literature review

Body composition in patients with rheumatoid arthritis: a narrative literature review

What Role Does Trabecular Bone Score Play in Chronic Inflammatory Rheumatic Diseases?

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