SATB2 overexpression promotes oral squamous cell carcinoma progression by up-regulating NOX4

Gao, Jie; Meng, Ying; Hou, Chen‐Xing; Zhu, Quing; Wang, Yizhou; Sun, Li-Fan; Wang, Chen-Xing; Li, Huaiqi; Zhang, Tianzhu; Ye, Jinhai

doi:10.1016/j.cellsig.2021.109968

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…The subsequent screening step by both title and abstract resulted in 23 studies being included. Full‐text screening of the included studies resulted in 14 being selected for review 1,4,6,17,37,44,49–58 . A flowchart that depicts the screening process is displayed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Full‐text screening of the included studies resulted in 14 being selected for review. 1 , 4 , 6 , 17 , 37 , 44 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 A flowchart that depicts the screening process is displayed in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Although distant metastasis occurs in about 10% of OSCC patients, this pathological process causes a poor prognosis and a significantly extended recovery 70 . According to the investigated studies, the HMGA2 and CSN6 genes promote the distant metastasis of OSCC 1,37 . Additionally, IFIR1,3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8 1,6,17,49–52 .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple factors are engaged in the occurrence and development of metastasis. Under the simultaneous effects of various pathogenesis (including genetic and environmental factors), the DNA mutations in normal cells activate proto‐oncogenes and disrupt the function of tumor suppressor genes, resulting in impaired cell growth and division 36–40 . Malignant and normal cells have different gene activity states, resulting in other protein syntheses, which ultimately lead to further cell functions 41,42 .…”

Section: Introductionmentioning

confidence: 99%

“…Under the simultaneous effects of various pathogenesis (including genetic and environmental factors), the DNA mutations in normal cells activate proto‐oncogenes and disrupt the function of tumor suppressor genes, resulting in impaired cell growth and division. 36 , 37 , 38 , 39 , 40 Malignant and normal cells have different gene activity states, resulting in other protein syntheses, which ultimately lead to further cell functions. 41 , 42 Consequently, identifying tumor markers may offer a more accurate, rapid, practical, and affordable technique for the early prognostic and diagnostic advancement of malignancies to prevent metastasis and attenuate mortality rates.…”

Section: Introductionmentioning

confidence: 99%

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Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Mohtasham,

Zarepoor,

Shooshtari

et al. 2024

Health Science Reports

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Background and AimsOral squamous cell carcinoma is the most prevalent malignancy in the oral cavity, with a significant mortality rate. In oral squamous cell carcinoma patients, the survival rate could decrease because of delayed diagnosis. Thus, prevention, early diagnosis, and appropriate treatment can effectively increase the survival rate in patients. In this systematic review, we discussed the role of different genes in oral squamous cell carcinoma metastasis. Herein, we aimed to summarize clinical results, regarding the potential genes that promote oral squamous cell carcinoma metastasis.MethodsThis systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non‐English language.ResultsA total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon‐induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high‐mobility group A2 (HMGA2), transformed growth factor‐beta‐induced, lectin galactoside‐binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5′−3′ exoribonuclease 2 (XRN2), cystatin‐A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin‐3, also known as P‐cadherin and Wnt family member 5A, ubiquitin‐specific‐processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.ConclusionStudies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Mohtasham,

Zarepoor,

Shooshtari

et al. 2024

Health Science Reports

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Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer

et al. 2022

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Utility of SATB2 and MOC-31 Immunostains to Distinguish Between Poorly Differentiated Rectal Adenocarcinoma and Anal Squamous Cell Carcinoma

Fang,

Assarzadegan,

Cheng

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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Objectives: Colorectal adenocarcinoma and squamous cell carcinoma (SCC) can arise in the anorectum and present a significant diagnostic challenge when poorly differentiated. Accurate diagnosis can significantly influence management, as the treatments for these conditions involve distinct neoadjuvant chemoradiotherapy regimens. MOC-31 and SATB2 have been utilized as specific markers of glandular differentiation and colorectal origin, respectively, but studies have shown that they may be positive in squamous cell carcinoma of other sites. This raises the concern that MOC-31 and SATB2 may be positive in squamous cell carcinoma of the anorectum, and overreliance on these stains may be a potential diagnostic pitfall in differentiating rectal poorly differentiated adenocarcinoma (PDA) from anal nonkeratinizing SCC. Methods: We identified biopsies from 10 rectal PDA and 17 anorectal nonkeratinizing SCC cases and stained them for MOC-31 and SATB2. Results: We found that MOC-31 was highly sensitive, being positive in 10/10 cases of rectal PDA, but not specific, as it was also positive in 11/17 SCC cases. In contrast, SATB2 was both sensitive, with positive staining in 10/10 rectal PDA cases, and specific, with negative staining in 17/17 SCC cases. This includes equivocal staining in 4 of these negative SCC cases. MOC-31 had a sensitivity of 100% and specificity of 35.3%, while SATB2 had a sensitivity of 100% and specificity of 100%. Conclusions: Unlike squamous mucosa of the head and neck, and esophagus, SCC of the anus does not frequently stain positively for SATB2. These data suggest that SATB2 is a reliable marker in distinguishing rectal PDA from anorectal nonkeratinizing SCC, whereas MOC-31 is commonly positive in SCC of the anus. It is also important to note that equivocal SATB2 staining may be seen in SCC.

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SATB2 overexpression promotes oral squamous cell carcinoma progression by up-regulating NOX4

Cited by 4 publications

References 7 publications

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer

Utility of SATB2 and MOC-31 Immunostains to Distinguish Between Poorly Differentiated Rectal Adenocarcinoma and Anal Squamous Cell Carcinoma

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