Satellite cell content and muscle regeneration in a mouse model of NAFLD

Saliu, Tolulope Peter; Kumrungsee, Thanutchaporn; Mitsumoto, Koji; Chen, Siyi

doi:10.1016/j.nut.2021.111570

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Mechanisms Of Regeneration In Ctx-induced Injury Models1

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2022

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“…Nonalcoholic fatty liver disease (NAFLD) reduces the SC pool and impairs SC differentiation, leading to attenuated skeletal muscle regeneration. This may be associated with TNF-α upregulation and increased levels of oxidative stress marker nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (NOX 2) [ 47 ]. The inhibition of carbonyl reductase1 (CBR1) leads to increased ROS levels and diminishes myoblast differentiation [ 216 ].…”

Section: Mechanisms Of Regeneration In Ctx-induced Injury Modelsmentioning

confidence: 99%

Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models

Wang

Liu

2022

IJMS

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Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the mechanisms of regeneration is critical for accelerating the repair and regeneration of muscle. Therefore, this article reviews knowledge on the mechanisms of skeletal muscle regeneration after cardiotoxin-induced injury. The process of regeneration is similar in different mouse strains and is inhibited by aging, obesity, and diabetes. Exercise, microcurrent electrical neuromuscular stimulation, and mechanical loading improve regeneration. The mechanisms of regeneration are complex and strain-dependent, and changes in functional proteins involved in the processes of necrotic fiber debris clearance, M1 to M2 macrophage conversion, SC activation, myoblast proliferation, differentiation and fusion, and fibrosis and calcification influence the final outcome of the regenerative activity.

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Section: Mechanisms Of Regeneration In Ctx-induced Injury Modelsmentioning

confidence: 99%