Satellite cell heterogeneity and hierarchy in skeletal muscle

Ono, Yusuke

doi:10.7600/jpfsm.3.229

Cited by 6 publications

(6 citation statements)

References 46 publications

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“…Satellite cells are mitotically quiescent in healthy adult muscle, but are activated in response to stimulation, such as muscle damage, to differentiate into myoblasts and proliferate extensively (Ono 2014). Quiescent satellite cells express the transcription factor Pax7 in adult muscle.…”

Section: Muscle Stem Cell Functions Are Impaired In An Estrogen-deficmentioning

confidence: 99%

Estrogens maintain skeletal muscle and satellite cell functions

Kitajima

Ono

2016

Journal of Endocrinology

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125

115

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Estrogens have crucial roles in an extensive range of physiological functions regulating cellular proliferation and differentiation, development, homeostasis, and metabolism. Therefore, prolonged estrogen insufficiency influences various types of tissues expressing estrogen receptors (ERs). Although ERs are expressed in skeletal muscle and its stem cells, called satellite cells, how prolonged estrogen insufficiency affects their function remains unclear. In this study, we investigated the effect of estrogen reduction on muscle in young ovariectomized (OVX) female mice. We found that reduced estrogens resulted in muscle atrophy in a time-dependent manner. Muscle force generation was reduced in OVX mice. Interestingly, prolonged estrogen insufficiency shifted fiber types toward faster myosin heavy chain isoforms. The number of satellite cells per isolated myofiber was unchanged, while satellite cell expansion, differentiation, and self-renewal were all markedly impaired in OVX mice. Indeed, muscle regeneration was significantly compromised in OVX mice. Taken together, our results demonstrate that estrogens are essential for comprehensively maintaining muscle function with its insufficiency affecting muscle strength and regeneration in young female mice.

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Section: Muscle Stem Cell Functions Are Impaired In An Estrogen-deficmentioning

confidence: 99%

Estrogens maintain skeletal muscle and satellite cell functions

Kitajima

Ono

2016

Journal of Endocrinology

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125

115

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“…Muscle satellite cells play a crucial role in providing myonuclei for muscle repair and regeneration in adult muscle [ 21 , 22 ]. Our previous study revealed that prolonged estrogen-insufficient state affected satellite cell function and muscle regeneration in OVX female mice [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice

et al. 2017

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Estrogens play a key role in an extensive range of physiological functions in various types of tissues throughout the body in females. We previously showed that estrogen insufficiency caused muscle weakness that could be rescued by estrogen administration in a young female ovariectomized (OVX) mouse model. However, long-term estrogen replacement therapy increases risks of breast cancer and cardiovascular diseases. Soymilk contains plant-based protein and isoflavones that exert estrogen-like activity. Here we examined the effects of prolonged soymilk intake on muscle and its resident stem cells, called satellite cells, in the estrogen-insufficient model. Six-week-old C57BL/6 OVX female mice were fed with a dried soymilk-containing diet. We found that prolonged soymilk intake upregulated grip strength in OVX mice. Correspondingly, cross-sectional area of tibialis anterior muscle was significantly increased in OVX mice fed with soymilk. Furthermore, soymilk diet mitigated dysfunction of satellite cells isolated from OVX mice. Thus, these results indicated that prolonged soymilk intake is beneficial for improving muscle weakness in an estrogen-insufficient state in females.

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“…Tissue stem cells in adults retain the ability to proliferate, self‐renew, and differentiate throughout life to maintain tissue homeostasis and repair injuries. Understanding how the balance between self‐renewal and differentiation is regulated in satellite cells is central to elucidating how skeletal muscle maintains a stem cell pool and homeostasis throughout life (Relaix and Zammit ; Ono ; Wang et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Satellite cells are responsible for providing myonuclei for postnatal muscle growth, hypertrophy, repair, and regeneration in adults (Otto et al. ; Relaix and Zammit ; Ono ; Wang et al. ).…”

Section: Introductionmentioning

confidence: 99%

Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells

et al. 2015

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Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total-body γ-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to γ-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice.

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Satellite cell heterogeneity and hierarchy in skeletal muscle

Cited by 6 publications

References 46 publications

Estrogens maintain skeletal muscle and satellite cell functions

Estrogens maintain skeletal muscle and satellite cell functions

Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice

Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells

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