Satellite glial cells in sensory ganglia: from form to function

Hanani, Menachem

doi:10.1016/j.brainresrev.2004.09.001

Cited by 648 publications

(812 citation statements)

References 186 publications

(247 reference statements)

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“…Our findings are consistent with previous ultrastructural analysis that demonstrated that the satellite cells were bigger, more numerous and constituted a multilamellate cell sheath especially around large ganglion neurons (Pannese, 1981;Ledda et al, 2004). The glial envelope represents a barrier that partially controls the neuronal environment of the DRG, by regulating the uptake of glutamate and gamma-aminobutyric acid (GABA), and possibly also Kþ ions (Hanani, 2005). In addiction, in the DRG the degree of lanthanum penetration in the neuronal extracellular space increases with the number of satellite cells around the neurons (Shinder and Devor, 1994).…”

Section: Discussionsupporting

confidence: 92%

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Immunohistochemical Localization of Substance P And Cholecystokinin in the Dorsal Root Ganglia and Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)

Bombardi

Grandis

Nenzi

et al. 2010

The Anatomical Record

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The presence of substance P (SP) and cholecystokinin (CCK) immunoreactive neurons was examined in the bottlenose dolphin dorsal root ganglia (DRGs) and spinal cord by immunohistochemical techniques. SPpositive and CCK-immunoreactive neurons were respectively $50% and 1% of the total number of ganglion cells examined and especially belonged to small and medium-sized cell populations. Using double labeling techniques we observed that SP-and CCK-immunoreactivity coexisted in a very low number of primary afferent neurons (2.7%). Few SPimmunoreactive (IR) neurons (2.7%) were also CCK-positive. On the contrary, 65% of CCK-immunoreactive neurons contained SP. Interestingly, we observed CCK-immunoreactive satellite glial cells located around large cell class somata. Virtually no SP-IR and CCK-positive neurons were surrounded by peripheral CCK-immunoreactive satellite glial cells. The SP-IR and CCK-positive nerve fibers were particularly conspicuous in the superficial layers of the spinal cord. The present study indicates that SP and CCK only partially overlap in the thoracic, lumbar, and caudal DRGs of the bottlenose dolphin, suggesting that the majority of SP-IR ganglion neurons are lacking in CCK-immunoreactivity. The role of SPcontaining DRG neurons is discussed also in relation to the huge vascular spinal retia mirabilia typical of cetaceans. Anat Rec, 293:477-484, 2010. V V C 2010 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 92%

“…The satellite cells contribute also to signal transmission in sensory ganglia. In fact, they are able to respond to nitric oxide, ATP, bradykinin, and endothelins (Hanani, 2005). Finally, satellite cells are involved in the mechanism of pathogenic chronic pain (Dublin and Hanani, 2007).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Substance P And Cholecystokinin in the Dorsal Root Ganglia and Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)

Bombardi

Grandis

Nenzi

et al. 2010

The Anatomical Record

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“…Analysis of such mixed tissues has been routinely performed previously, but results need to be interpreted with appropriate caution. Spinal nerve damage leads to the activation of satellite cells in the DRG, 16,31 thus potentially contributing to the observed methylome alterations. As expected, the glial fibrillary acidic protein (GFAP), an astroglial marker that is also expressed by satellite cells, 32 was upregulated, emphasizing that glial activation took place within 24 h after nerve injury.…”

Section: Discussionmentioning

confidence: 99%

Plasticity of DNA methylation in a nerve injury model of pain

et al. 2015

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“…Functionally, satellite cells are responsible for maintaining the homeostasis of sensory neurons by regulating extracellular ion and nutrient levels within the DRG (For review see (Hanani, 2005). Following sciatic nerve axotomy in rats, satellite cells have been shown to undergo morphological changes (Woodham et al, 1989;Stephenson & Byers, 1995), proliferate (Shinder & Devor, 1994) and upregulate a variety of growth factors (Hammarberg et al, 1996;Zhou et al, 1999).…”

Section: Cellular Alterations In Satellite Cells Macrophages and Schmentioning

confidence: 99%

An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat

et al. 2007

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Paclitaxel (Taxol®) is a frontline antineoplastic agent used to treat a variety of solid tumors including breast, ovarian, or lung cancer. The major dose limiting side effect of paclitaxel is a peripheral sensory neuropathy that can last days to a lifetime. To begin to understand the cellular events that contribute to this neuropathy, we examined a marker of cell injury/regeneration (activating transcription factor 3; ATF3), macrophage hyperplasia/hypertrophy; satellite cell hypertrophy in the dorsal root ganglion (DRG) and sciatic nerve as well as astrocyte and microglial activation within the spinal cord at 1, 4, 6 and 10 days following intravenous infusion of therapeutically relevant doses of paclitaxel. At day 1 post-infusion there was an up-regulation of ATF3 in a subpopulation of large and small DRG neurons and this up-regulation was present through day 10. In contrast, hypertrophy of DRG satellite cells, hypertrophy and hyperplasia of CD68+ macrophages in the DRG and sciatic nerve, ATF3 expression in S100β+ Schwann cells and increased expression of the microglial marker (CD11b) and the astrocyte marker glial fibrillary acidic protein in the spinal cord were not observed until day 6 post infusion. The present results demonstrate that using the time points and markers examined, DRG neurons show the first sign of injury which is followed days later by other neuropathological changes in the DRG, peripheral nerve and dorsal horn of the spinal cord. Understanding the cellular changes that generate and maintain this neuropathy may allow the development of mechanism-based therapies to attenuate or block this frequently painful and debilitating condition.

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Satellite glial cells in sensory ganglia: from form to function

Cited by 648 publications

References 186 publications

Immunohistochemical Localization of Substance P And Cholecystokinin in the Dorsal Root Ganglia and Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)

Immunohistochemical Localization of Substance P And Cholecystokinin in the Dorsal Root Ganglia and Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)

Plasticity of DNA methylation in a nerve injury model of pain

An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat

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