Climate anomalies and human disturbances exert complex effects on regional carbon sequestration (CS), causing ecosystem CS to either increase or decrease due to factors such as vegetation greening, climate extremes, land use/land cover (LULC) changes, and farming systems. This study employs the patch-level land use simulation model to forecast changes in various land-use types in the Xinjiang Uyghur Autonomous Region, China, between 2020 and 2060 under different climatic conditions. The Intergovernmental Panel on Climate Change has proposed shared socioeconomic pathways (SSPs) as potential socioeconomic and environmental trajectories that might influence the region’s future land-use patterns. Three salient findings emerged: (1) LULC displayed considerable variation across future climate scenarios, with a notable rise in forest and grassland cover and a marked decrease in cropland areas under the SSP126 scenario. Conversely, the SSP585 scenario witnessed a substantial cropland expansion, paralleled by a decrease in forest and grassland areas; (2) CS exhibited significant disparities across different future climate scenarios. Xinjiang achieved a peak CS of 9.81 Pg between 2020 and 2060 under the SSP126 scenario, marking an increase of 335.22 Tg in 2060 compared to that in 2020. The SSP585 scenario registered the lowest CS at 9.41 Pg, indicating a decline of 50.07 Tg in 2060 relative to 2020; (3) The impacts of longitude and latitude on CS in Xinjiang predominantly arose from shifts in forest area and vegetation cover based on latitude, which positively influenced CS. In contrast, a decrease in vegetation cover and a subsequent decline in CS were evident with increasing longitude, particularly in the Altai, Tianshan, and Kunlun Mountains. These findings hold significant implications for formulating CS management strategies for terrestrial ecosystems and enhancing ecological preservation in Xinjiang.