Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation

Abstract

Objective: To test the effect on satiety of a formulation comprising plant extracts naturally containing 5-hydroxytryptophan, delivered as sublingual spray (5HTP-Nat Exts), administered five times a day for 2 months. Design: Two-month, randomized, double-blind, placebo-controlled trial. Subjects: A total of 27 healthy, adult overweight women were randomly assigned to the treatment (14) or the placebo group (13). Measurements: Visual analog scales were used to assess appetite sensations every day. Moreover, the study evaluated the bioavailability of 5-hydroxytryptophan following sublingual delivery over 8 weeks, by comparing 24-h urinary excretion of 5-hydroxy-3-indoleacetic acid (5-HIAA), determined at baseline and after 2 months. Other secondary end points of the study were to compare body composition, depressive symptoms, severity of binge eating and quality of life. Finally, the study tested whether a single administration of 5HTP-Nat Exts in fasting state has an effect on amino-acid profile and on appetite ratings and whether 5HTP-Nat Exts administered before a fixed test meal has any effect on satiety. Results: The group using the 5HTP-Nat Exts experienced a significantly greater increase in their sensation of satiety over an 8-week timeframe and in fasting state following administration of 5HTP-Nat Exts than the placebo group did (AUC ¼ 305.2 (52.8) vs 236.6 (59.4), mean difference À68.7 (95% confidence interval (CI) À116.2 to À21.2), P ¼ 0.007; mean difference in Haber score change 2.5 (95% CI 0.62-3.12, P ¼ 0.007)). A difference was observed between the groups for the mean change in 5-HIAA. All the amino acids evaluated after a single administration of 5HTP-Nat Exts were found to be similar. Differences were found for the mean change in body mass index, skinfold thicknesses and hip circumference. The other parameters were found to be similar. Conclusion: All these findings suggest that 5HTP-Nat Exts may be safely used to treat the problem of appetite control in overweight women during a weight loss program.

The effect of 12 weeks of euenergetic high-protein diet in regulating appetite and body composition of women with normal-weight obesity: a randomised controlled trial

“…All 24-h dietary recalls were completed (one weekday and one weekend day) at baseline and at the 4, 8 and 12 weeks' time points (39) . Participants were asked to recall the foods consumed over the previous 24 h. A 24-h period was defined as the time between when the participants woke up the previous day until the time they woke up the day of the interview (40) .…”

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

“…Besides, a significant decrease in appetite and increase in hunger was seen by P. vulgaris (with dose of 100 mg/day; Spadafranca et al, ), C. fimbriata (with dose of 1,000 mg/day; Kuriyan et al, ), spinach (with dose of 5,000 mg/day; Rebello et al, , Stenblom, Egecioglu, Landin‐olsson, & Erlanson‐albertsson, ), flaxseed (with dose of 2,500 mg/day; Ibrugger, Kristensen, Mikkelsen, & Astrup, ), fenugreek (with dose of 8,000 mg/day; Mathern, Raatz, Thomas, & Slavin, ), G. cambogia (with dose of 1,000 mg/day; Mayer et al, , Preuss et al, ), green coffee (Roshan, Nikpayam, Sedaghat, & Sohrab, ), and the combination simplicifolia , asiatica , Taraxacum officinale , Cynara Scolymus , Paullina Sorbilis , Alga Klamath (Rondanelli, Klersy, Iadarola, Monteferrario, & Opizzi, ), and a combination of G. cambogia and Amorphophallus konjac (Vasques et al, ; Figure ). Some other articles have shown that Gundelia tournefortii (Hajizadeh‐Sharafabad, Alizadeh, Mohammadzadeh, Alizadeh‐Salteh, & Kheirouri, ), Coleus forskohlii (Loftus et al, ), N. sativa (Mahdavi et al, ), Garcinia atroviridis (Roongpisuthipong, Kantawan, & Roongpisuthipong, ), C. fimbriata (Kuriyan et al, ), a combination of ephedra and caffeine (Hackman et al, ) as well as a combination of walnut and flaxseed (Wu et al, ) significantly reduces energy intake (Figure ).…”

Griffonia simplicifolia

“…Aufbauend auf einer randomisierten, doppelblinden, placebokontrollierten Pi lotstudie (29) wurde eine ebensolche Stu die mit 20 übergewichtigen Frauen durch geführt. Die Probandinnen wurden ange wiesen, zu den persönlich abgestimmten,…”