Satiety, glycemic profiles, total antioxidant capacity, and postprandial glycemic responses to different sugars in healthy Malaysian adults

Azlan, Azrina; Ebadi, Samarghand; Yusof, Barakatun Nisak Mohd; Othman, Nur Maziah Hanum; Kannar, David; Sultana, Sharmin; Mahmood, Zhafarina

doi:10.1016/j.nut.2021.111551

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…The antioxidant activity of NCS products has been widely characterized, both in vitro and in vivo . Notably, NCS has shown antioxidant activities in human blood plasma as short as 60 min after consumption ( Azlan et al, 2022 ) and stimulating effects over antioxidant enzymes (e.g., superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase) in mouse models ( Kinjo et al, 2019 ; N. Singh et al, 2010 ). Accordingly, to evaluate if the modified production methods had any effect over the already described antioxidant potential of the resulting end products, we characterized the scavenging profiles of sugarcane-derived extracts in the presence of chemical radicals.…”

Section: Resultsmentioning

confidence: 99%

Section: All Ncs Extracts Exhibit High Yet Comparable Chemical Radica...mentioning

confidence: 99%

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Evaluating the Impact of Thermal Processing on the Anti-Inflammatory Activity of Non-Centrifugal Cane Sugar: Implications on Cytokine Secretion and TLR4 Signaling

Rueda-Gensini

Serna²,

Bolaños³

et al. 2022

Front. Pharmacol.

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Plant-derived products have gained considerable attention as inflammation modulators given the wide variety of anti-inflammatory phytochemicals reported to be present in plants and their limited side effects in vivo during prolonged exposure periods. Non-centrifugal cane sugar (NCS) has been identified as a promising sugarcane-derived product due to its high polyphenolic composition and antioxidant potential, but its incorporations into nutraceuticals and other relevant products of biomedical interest has been limited by the ample composition-wise variability resulting from extreme and loosely controlled processing conditions. Here, we assessed the effect of reducing thermal exposure during NCS processing on the retained polyphenolic profiles, as well as on their antioxidant and anti-inflammatory activities. Specifically, we proposed two modified NCS production methods that reduce exposure to unwanted thermal processing conditions by 1) limiting the employed temperatures through vacuum-aided dehydration and 2) by reducing exposure time through refractance window evaporation. By comparing the modified NCS products with traditional NCS, we showed that the proposed process strategies yield enhanced polyphenolic profiles, as evidenced by the results of the Folin-Ciocalteu polyphenol quantification method and the components identification by HPLC coupled to mass spectrometry. Although these compositional differences failed to impact the antioxidant profiles and cytocompatibility of the products, they showed an enhanced anti-inflammatory potential, given their superior modulation capacity of inflammatory cytokine secretion in both systemic and neuroinflammatory scenarios in vitro. Moreover, we showed that both modified NCS products interfere with TLR4 signaling in human monocytes to a significantly greater extent than traditional NCS. However, the anti-inflammatory effect of NCS produced under window refractance evaporation was slightly superior than under vacuum-aided dehydration, demonstrating that reducing exposure time to high temperatures is likely more effective than reducing the operation temperature. Overall, these findings demonstrated that limiting thermal exposure is beneficial for the development of NCS-based natural products with superior anti-inflammatory potential, which can be further exploited in the rational design of more potent nutraceuticals for potentially preventing chronic inflammatory diseases.

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Section: Resultsmentioning

confidence: 99%

Section: All Ncs Extracts Exhibit High Yet Comparable Chemical Radica...mentioning

confidence: 99%

Evaluating the Impact of Thermal Processing on the Anti-Inflammatory Activity of Non-Centrifugal Cane Sugar: Implications on Cytokine Secretion and TLR4 Signaling

Rueda-Gensini

Serna²,

Bolaños³

et al. 2022

Front. Pharmacol.

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“…[ 40 ] A recent randomized crossover clinical trial showed that the intake of jelly prepared using MRBS resulted in a significantly higher total antioxidant capacity (TAC) in healthy participants than in granulated white sugar jelly. [ 41 ] Thus, the health benefits of less refined sugar may encourage both industries and the public to substitute white sugar with less refined sugar in sugar-based food products and dietary sugar intake to increase antioxidant intake. The importance of antioxidant activity in NCS can be observed by the frequent usage of refined sugar consumption calculated per capita in Spain (~340 g/month).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Unrefined Sugar on Inflammation: A Systematic Review of Intervention Studies

Ebadi,

Azlan

2023

International Journal of Preventive Medicine

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Background: It is well established that unrefined sugarcane products have antioxidant activity due to phytochemicals, polyphenols, and total antioxidant capacity, which may decrease inflammation and oxidative stress. Therefore, we conducted a systematic review to evaluate the association of unrefined sugar consumption with inflammatory biomarkers. Methods: Google Scholar, ScienceDirect, Scopus, Cochrane Library, and ProQuest databases were searched up to December 2021 for studies that report the effect of unrefined sugar on inflammation according to inflammatory cytokines, chemokine, and adhesion molecules as outcome measures. Results: Thirty-six studies were evaluated. Across all research, five studies (two in vitro and three animal studies) reported the effect of unrefined sugar on levels of cytokines, including IL-6, TNF-α, IL-10, IL-1β, and IFN-γ. Additionally, the quality of the studies was assessed for risk of bias. Conclusions: it is possible to affirm that unrefined sugarcane products, including jaggery, may have a protective effect on inflammation via regulating some of the inflammatory pathways and a favorable impact on cytokines secretion according to the results of in vitro and animal model studies. However, since the findings are still insufficient, more scientific research, especially well-designed human trials, is highly recommended to conclude the outcomes confidently. Human data may encourage industries and the public to replace purified sugar with unrefined sugarcane in sugar-based food and for further health-care policy decisions.

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“…However, greater D-glucose contents were obtained at the end of the intestinal phase due to the action of pancreatic α-amylase, which favours the amylolytic process (Freitas et al, 2018), being the levels of D-glucose lower when simulating saliva deficiency along with loss of force. In this regard, it is important to remark that an increase in blood glucose concentrations is associated with slower gastric emptying, contributing to fullness and short-term satiety (Azlan et al, 2022). Thus, cumulative oral deficiencies could also favour the prevalence or development of metabolic syndromes, obesity, and cardiovascular diseases, which are linked to gastric emptying, fullness, and satiety.…”

Section: Impact Of Mastication On Nutrient Bioaccessibilitymentioning

confidence: 99%

Oral impairments decrease the nutrient bioaccessibility of bread in the elderly

et al. 2023

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Satiety, glycemic profiles, total antioxidant capacity, and postprandial glycemic responses to different sugars in healthy Malaysian adults

Cited by 10 publications

References 49 publications

Evaluating the Impact of Thermal Processing on the Anti-Inflammatory Activity of Non-Centrifugal Cane Sugar: Implications on Cytokine Secretion and TLR4 Signaling

Evaluating the Impact of Thermal Processing on the Anti-Inflammatory Activity of Non-Centrifugal Cane Sugar: Implications on Cytokine Secretion and TLR4 Signaling

The Effect of Unrefined Sugar on Inflammation: A Systematic Review of Intervention Studies

Oral impairments decrease the nutrient bioaccessibility of bread in the elderly

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