Satiety testing: Ready for the clinic?

Jones, Michael P.

doi:10.3748/wjg.14.5371

Cited by 12 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Nutrient drink tests were developed as a symptom provocative technique for patients with dyspeptic complaints. 4 Male ingest greater volumes than female patients but there BMI. 4 Our study also showed similar results.…”

Section: Discussionmentioning

confidence: 99%

“…4 Male ingest greater volumes than female patients but there BMI. 4 Our study also showed similar results. But in FD patients, male and female ingested similar volume, it was because of impaired gastric accommodation.…”

Section: Discussionmentioning

confidence: 99%

“…Many study showed that patients with FD will often achieve satiation at lower drink test volumes and report greater dyspepsia symptoms than healthy controls during the test. 4 Ghrelin (deacylated and acylated form) is the endogenous ligand for the growth hormone secretagogue receptor, and it has potent growth hormone-releasing activity. The physiologic function of ghrelin are pleiotropic to stimulate food intake, regulaes gastric acid secretion, promotes gastric emptying and generation of nitric oxide and prostaglandins.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

Cahyono

Ratnasari

Bayupurnama

et al. 2015

InaJGHE

View full text Add to dashboard Cite

Background: Impaired gastric accommodation and visceral hypersensitivity are major pathophysiological mechanism in functional dyspepsia (FD). Ghrelin, as gut hormone, may play a pathophysiological role in functional dyspepsia. Nutrient drink test was developed to assess impaired gastric accommodation in FD patients. The aims of this study are to compare maximum tolerated volume, postprandial symptoms and acylated ghrelin levels between dyspepsia functional patients and healthy subjects as controls.Method: A cross sectional study was conducted from July 2014 to November 2014, at Sardjito General Hospital, Yogyakarta. Twenties functional dyspepsia patients and 20 healthy subjects ingested nutrient drink tests (Ultra Milk contain 0.6 kcal/mL). The maximum tolerated volume was recorded. After ingested maximal tolerated volume, nausea, bloating and pain were rated using visual analogue scales (VAS) with 100 mm lines. The levels of acylated ghrelin was recorded before and 30 minutes after maximal drinking.Results: The demographic characteristics (age, sex, and body mass index) between dyspepsia patients and healthy subjects were compared. Patients with functional dyspepsia ingested 600 (350–1000) mL and healthy subjects ingested 1375 (1000–1900) mL (p 0.001). The total symptom scores were higher in dyspepsia patients compared healthy subjects; 215 (110–350) vs. 75 (50–120) (p 0,001). The fasting plasma levels of acylated ghrelin (20.65 : 2 – 31.37 pg/mL) in FD patients were significantly lower than healthy subjects (30.61 : 2 – 251.19 pg/mL) ( p = 0.012). Conclusion: Patients with functional dyspepsia ingested significantly lower volume and significantly have higher score symptoms than healthy subjects. The fasting plasma levels of acylated ghrelin in functional dyspepsia patients were significantly lower than healthy subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

Cahyono

Ratnasari

Bayupurnama

et al. 2015

InaJGHE

View full text Add to dashboard Cite

show abstract

“…Different nutrient drink tests based on various nutrient containing solutions, are performed with various drinking rates 1-3. Nutrient drink test developed by Mayo Clinic presents the simplest method among other tests 4. Subjects consume 120 mL of Ensure™ (Abbott Laboratories, Abbott Park, IL, USA), which contains 1.06 kcal/mL with 65% of carbohydrate, 20% of fat and 15% of protein, every 4 minutes until full 5.…”

Section: Performing Nutrient Drink Testsmentioning

confidence: 99%

How to Interpret Nutrition Drink Test

Park¹

2011

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Nutrient drink test is one of the drink test techniques to assess gastric accommodation and to quantify meal-induced symptoms. It uses nutrient-containing solution instead of water and has been proposed as a surrogate method for estimating gastric volumes and validated for assessing satiation, sensation of bothersome symptoms after meal ingestion. Various nutrient-containing solution and drinking rates have been used and there were no widely accepted reference values for nutrient drink test until now. However, tests results are usually reported as the maximum tolerated volume, individual and cumulative symptom scores. The accommodation response, gastric sensation and gastric emptying may influence the maximum tolerated volume of nutrient drink. Although drink test is a useful tool for assessing gastric accommodation and sensation, it remains unclear exactly what physiologic processes are assessed by nutrient drink tests.

show abstract

“…Recently, good reproducibility of the drinking test has been shown [12]. In contrast, other investigators have found that drinking tests are a less sensitive predictor of impaired accommodation or visceral hypersensitivity than the barostat study [13]. No data are available on the usefulness of drinking tests in comparison with the gold standard method, the barostat, in Japan.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of a Slow Nutrient Drinking Test for Evaluating Gastric Perception and Accommodation

et al. 2011

View full text Add to dashboard Cite

Background/Aim: An implication of the drinking test for gastric function is controversial. We evaluated the usefulness of a nutrient drinking test for examining gastric function by comparing it with a gastric barostat study. Methods: We investigated perceived pressure of an intragastric bag with stepwise distension and postprandial peak gastric volume (accommodation volume) with a consistent pressure after drinking a liquid meal (200 ml, 300 kcal) in 18 volunteers. Drinking a similar liquid meal on a different day at a continual rate of 15 ml/min was performed to score satiety and bloated sensations at 5-min intervals. An additional 10 volunteers performed the drinking test before and after administration of mosapride citrate or a placebo in a double-blind crossover study. Results: Pressure to induce severe discomfort correlated positively with maximum satiety volume in the drinking test (r = 0.60, p = 0.02). Accommodation volume in the barostat study showed a significant correlation (r = 0.59, p = 0.03) with threshold volume to induce bloating in the drinking test. Mosapride tended to increase the volume inducing the first bloated sensation as compared to the placebo. Conclusion: The present drinking test may be useful for evaluating the threshold to induce severe discomfort and accommodation volume.

show abstract

Satiety testing: Ready for the clinic?

Cited by 12 publications

References 20 publications

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

How to Interpret Nutrition Drink Test

Usefulness of a Slow Nutrient Drinking Test for Evaluating Gastric Perception and Accommodation

Contact Info

Product

Resources

About