Satisfaction After Contralateral Prophylactic Mastectomy: The Significance of Mastectomy Type, Reconstructive Complications, and Body Appearance

Frost, Marlene H.; Slezak, Jeffrey M.; Tran, Nho V.; Williams, Constance I.; Johnson, Joanne L.; Woods, John E.; Petty, Paul M.; Donohue, John H.; Grant, Clive S.; Sloan, Jeff A.; Sellers, Thomas A.; Hartmann, Lynn C.

doi:10.1200/jco.2005.09.233

Cited by 189 publications

(151 citation statements)

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“…Moreover, measurable morbidity rates and negative psychological impacts were found to be associated with prophylactic mastectomy [39,40]. Secondly, BCT was described as a safe and efficacious treatment option for treating early stage cancer [11,27,41,42].…”

Section: Discussionmentioning

confidence: 99%

Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics

Kheirelseid

Jumustafa

Miller

et al. 2010

Breast Cancer Res Treat

144

133

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Section: Discussionmentioning

confidence: 99%

Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics

Kheirelseid

Jumustafa

Miller

et al. 2010

Breast Cancer Res Treat

144

133

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“…[7][8][9] Overall, most women reported high levels of satisfaction, 8,9 favorable effects on emotional stability and stress, 8 and significantly lower levels of breast cancer concerns than women who had not undergone CPM. 9 Distress levels and quality of life were comparable with those of women who did not undergo CPM.…”

mentioning

confidence: 97%

“…9 Distress levels and quality of life were comparable with those of women who did not undergo CPM. 9 Negative effects were reported for body appearance, sense of femininity, 8 and sexuality. 7 However, these were all retrospective studies focusing on a delayed CPM in patients not aware of their genetic status at the time of their breast cancer diagnosis 8,9 or describing a group of both affected and unaffected women.…”

mentioning

confidence: 99%

“…9 Negative effects were reported for body appearance, sense of femininity, 8 and sexuality. 7 However, these were all retrospective studies focusing on a delayed CPM in patients not aware of their genetic status at the time of their breast cancer diagnosis 8,9 or describing a group of both affected and unaffected women. 7 Less is known about the psychosocial impact of RGCT and of immediate CPM at the time of the initial breast cancer diagnosis.…”

mentioning

confidence: 99%

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Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial

Wevers

Ausems

Verhoef

et al. 2016

Genetics in Medicine

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Original research article IntroductIonFemale breast cancer patients who carry a BRCA1 or BRCA2 gene mutation have an increased risk of 20-55% for developing a second primary breast cancer 1 and are at increased risk for ovarian cancer. The risk of contralateral breast cancer is highest for carriers who were diagnosed with their first breast cancer at a young age. 1 Between 18 and 29% of carriers with a favorable prognosis opt for immediate or, more often, delayed contralateral prophylactic mastectomy (CPM) to reduce their risk of a second breast cancer. [2][3][4] Several studies have shown that a CPM leads to a large reduction (up to 95%) in the risk of contralateral breast cancer, with increasing evidence of improved breast cancer-specific survival. 5,6 Advances in the technology and logistics of genetic testing of the BRCA1 and BRCA2 genes have made it possible to offer high-risk breast cancer patients the opportunity to undergo rapid genetic counseling and testing (RGCT) during the time period between diagnosis and primary surgery. Women who Purpose: Female breast cancer patients carrying a BRCA1/2 mutation have an increased risk of second primary breast cancer. Rapid genetic counseling and testing (RGCT) before surgery may influence choice of primary surgical treatment. In this article, we report on the psychosocial impact of RGCT. Methods:Newly diagnosed breast cancer patients at risk for carrying a BRCA1/2 mutation were randomized to an intervention group (offer of RGCT) or a usual care control group (ratio 2:1). Psychosocial impact and quality of life were assessed with the Impact of Events Scale, Hospital Anxiety and Depression Scale, Cancer Worry Scale, and the EORTC QLQ-C30 and QLQ-BR23. Assessments took place at study entry and at 6-and 12-month follow-up visits.results: Between 2008 and 2010, 265 patients were recruited into the study. Completeness of follow-up data was more than 90%. Of the 178 women in the intervention group, 177 had genetic counseling, of whom 71 (40%) had rapid DNA testing and 59 (33%) received test results before surgery. Intention-to-treat and per-protocol analyses showed no statistically significant differences between groups over time in any of the psychosocial outcomes. conclusions:In this study, RGCT in newly diagnosed breast cancer patients did not have any measurable adverse psychosocial effects.

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“…Fourth, prospective tracking of psychological aspects of CPM and how CPM affects body image, self-assurance, and sexuality is needed. Although these topics have been addressed in older studies, 75,99 what value women place on their body image and their breast appearance has likely changed since these publications, and likely plays a large role in decision making regarding CPM.…”

Section: Discussionmentioning

confidence: 99%

Contralateral Prophylactic Mastectomy: Current Perspectives

Yao¹

2017

Changing Paradigms in the Management of Breast Cancer

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Satisfaction After Contralateral Prophylactic Mastectomy: The Significance of Mastectomy Type, Reconstructive Complications, and Body Appearance

Abstract: Although most women are satisfied with CPM, each woman should weigh the benefits alongside the potential adverse effects.

Cited by 189 publications

References 20 publications

Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics

Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics

Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial

Contralateral Prophylactic Mastectomy: Current Perspectives

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