IntroductionFacial thread lifting is a highly demanded procedure in esthetic clinics worldwide. The aim of this retrospective study is to evaluate the clinical effectiveness and overall patients’ satisfaction of a new generation of barbed threads, in which a hyaluronic acid (HA) coat was added to the PLLA/PCL threads and compare the results with PLLA/PCL threads without HA.Materials and methodsTwenty patients treated with the PLLA/PCL threads with or without hyaluronic acid (HA) were compared for FaceQ scales: Age appraisal, psychological function, skin satisfaction, satisfaction with facial appearance, appraisal lines of nasolabial folds, satisfaction of lower face, and jaw were compared at baseline, 4 and 12 months post‐treatment. Early impact on life and the skin adverse effects were assessed 1 week post‐treatment. Finally, patients and two physicians provided the GAIS score at 4 and 12 months and a comparison was made between the two groups.ResultsThere was a statistically significant improvement in all scales of FaceQ for all included patients at baseline and at 4 and 12 months post‐treatment. Importantly, there were less skin‐related adverse effects such as skin redness, uneven tone, irregular surface, burning, and itching sensation at a recovery period (1 week post‐treatment) in the group receiving HA‐containing threads.ConclusionA notably higher long‐term improvement in aging appearance, satisfaction with face appearance, lower jaw and face as well as GAIS was seen in the group treated with HA‐containing threads compared to the other treatment arm.