The cleft lip and palate (CLP) is the second most common congenital anomaly in the world; therefore, understanding the quality of life in children and adolescents with this malformation is extremely important. The study of the quality of life in this population is based on how the patient feels about his condition and how it affects his general well-being depending on the problems he may encounter concerning bone growth, phonation, speaking, facial appearance, and social relationship. As part of a descriptive survey, the aim was to assess and study the quality of life of patients with labio-palatal clefts operated and undergoing medical management, as well as the quality of life perceived by their parents to evaluate the family impact of this dysmorphia. According to the studies, teenagers had the lowest quality of life rates in the items: physical appearance and self-esteem, so the psychological support for patients and their families with multidisciplinary treatment that meets standards, are the keys to improving the quality of life of this category of patients.