Purpose To conduct a systematic review and meta-analysis of quality of life (QoL) outcomes for people with serious mental illness living in three types of supported accommodation. Methods Studies were identified that described QoL outcomes for people with serious mental illness living in supported accommodation in six electronic databases. We applied a random-effects model to derive the meta-analytic results. Results 13 studies from 7 countries were included, with 3276 participants receiving high support (457), supported housing (1576) and floating outreach (1243). QoL outcomes related to wellbeing, living conditions and social functioning were compared between different supported accommodation types. Living condition outcomes were better for people living in supported housing (g = − 0.31; CI = [− 0.47; − 0.16]) and floating outreach (g = − 0.95; CI = [− 1.30; − 0.61]) compared to high-support accommodation, with a medium effect size for living condition outcomes between supported housing and floating outreach (g = − 0.40; CI = [− 0.82; 0.03]), indicating that living conditions are better for people living in floating outreach. Social functioning outcomes were significant for people living in supported housing compared to high support (g = − 0.37; CI = [− 0.65; − 0.09]), with wellbeing outcomes not significant between the three types of supported accommodation. Conclusion There is evidence that satisfaction with living conditions differs across supported accommodation types. The results suggest there is a need to focus on improving social functioning and wellbeing outcomes for people with serious mental illness across supported accommodation types.