Sativa seeds against Schistosoma mansoni different stages

Mohamed, Azza M.; Metwally, Nadia M; Mahmoud, S. S.

doi:10.1590/s0074-02762005000200016

Cited by 81 publications

(62 citation statements)

References 47 publications

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“…N. sativa seeds also induced an oxidative stress against adult worms which indicated by a decrease in the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the anti-schistosomal potency of the N. sativa seed [35] . The antioxidant and anti-schistosomal activities of the garlic extract (AGE) and NSO on normal and Schistosoma mansoni-infected mice was investigated.…”

Section: Anti-schistosomiasis Activitymentioning

confidence: 99%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,122

796

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Section: Anti-schistosomiasis Activitymentioning

confidence: 99%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,122

796

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“…The spread of schistosomiasis endemic areas and increasing infection rate [1][2][3][4][5][6][7][8][9] support the need of new drug discovery and development [5][6][7][8][9]. Research of natural products has provided remarkable new drugs or drug leads to combat several diseases [14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, PZQ has only a limited effect on already developed liver and spleen lesions and there is a considerable concern about the development of PZQ resistance [8,9]. Such facts have encouraged the scientific community to develop novel and inexpensive drugs against schistosomiasis [7][8][9]. In this regard, a number of studies have been developed with natural products from medicinal plants to identify a leading compound that can be used for the treatment of schistosomiasis [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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In vivo and In vitro of Arctiin Schistosomicidal Activity

LC¹,

MM²,

PM³

et al. 2017

Clin Exp Pharmacol

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Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more 200 million individuals worldwide and praziquantel is the only available drug to treat this neglected disease. Arctiin is a lignan obtained from Arctium lappa (Asteraceae) with antiinflammatory and antiproliferative activities. Our purpose was to investigate the in vitro and in vivo schistosomicidal activities of arctiin in mice infected with S. mansoni. Arctiin (200 and 100 μM) caused mortality, tegumental alterations, and reduction of motor activity of adult worms of S. mansoni in culture. Oral administration of a single dose of arctiin (25 mg/kg) on day 45 of infection did not reduce worm burden or cause any alteration in the analyzed parameters when compared to infected untreated mice. On the other hand, intraperitoneal treatment with arctiin (50 mg/kg) was able to reduce the hepatic granuloma volume by 20% in comparison to infected untreated mice. In addition, after intraperitoneal administration of arctiin in mice it was shown by HPLC analysis that arctiin was present in murine plasma. More studies should be conducted to verify the possible mechanism of action on inflammatory components present in granuloma formation.

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“…As a result, research with medicinal plants constitutes a very viable alternative. In this scenario, several studies and researches on natural bioactive products extracted from plants and used against schistosomiasis have been carried out in the search for a new medicine that can replace praziquantel or complement it (Xiao & Catto, 1989, Molgaard et al, 2001, Mahmoud et al, 2002, Mohamed et al, 2005, Shaohong et al, 2005, Penido et al, 2008, Moraes et al, 2010. Taking into account the great variety of plants that haven't yet been therapeutically studied to combat S. mansoni schistosomiasis, in recent years our research group started a multidisciplinary project to perform in vitro screening of extracts from native and exotic plants commonly cultivated in Brazil.…”

mentioning

confidence: 99%