SATR-1 hypomethylation is a common and early event in breast cancer

Costa, Fabrício F.; Paixão, Valéria A.; Cavalher, Felícia P.; Ribeiro, Karina de Cássia Braga; Cunha, Isabela Werneck da; Rinck, José Augusto; O’Hare, Michael J.; Mackay, Alan; Soares, Fernando Augusto; Brentani, Ricardo R.; Camargo, Anamaria A.

doi:10.1016/j.cancergencyto.2005.07.023

Cited by 45 publications

(27 citation statements)

References 28 publications

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“…This finding suggests that global DNA hypomethylation may contribute to CLL tumor progression, likely promoting genomic instability as a consequence of destabilization of repetitive sequences. 31,32 Hypomethylation of DNA satellite repeats in pericentromeric regions has been shown to lead to chromatin decondensation and consequent chromosomal fragility. The high frequency of chromosome rearrangements/breakpoints found in different cancer types and associated with tumor progression has been correlated with a marked role of satellite repeats hypomethylation.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

Fabris

Bollati

Agnelli³

et al. 2011

Epigenetics

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

Fabris

Bollati

Agnelli³

et al. 2011

Epigenetics

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“…The resultant aberrant transcription and chromosomal instability is believed to contribute to disease onset or progression and increased tumor frequency and malignancy, a disease-specific factor. Global hypomethylation appears to be an early event for colon and breast cancer (Costa et al 2006;Kondo and Issa 2004;Lin et al 2001). With regard to hematological malignancies, hypomethylation has been reported in chronic lymphocytic leukemia (Wilson et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The role of MTHFR gene in multiple myeloma

et al. 2008

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Case-control studies investigating associations between multiple myeloma (MM) and the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) have provided controversial results. In an attempt to interpret these results, a meta-analysis of all available studies was performed. In the meta-analysis the pooled odds ratios (OR) were estimated using fixed effects (FE) and random effects (RE) models. The heterogeneity between studies, the sources of potential bias and the consistency of genetic effects across ethnicities were explored. Cumulative meta-analysis was also performed. The meta-analysis revealed non-significant heterogeneity between studies (P q C 0.65). The dominant model for the effect of 677T allele produced significant association overall [FE OR = 1.23 (1.04-1.47)] and in Caucasians [FE OR = 1.54 (1.14-2.08)], but not in East Asians [FE OR = 1.05 (0.82-1.34)]. Although the cumulative metaanalysis for the dominant model of 677T allele showed a downward trend of RE OR for the period 2000-2007, the association still remained significant. Analysis of the A1298C polymorphisms revealed lack of association both in Caucasians and in East Asians. There is an indication of potential bias: a differential magnitude of effect in large versus small studies emerged. In conclusion, the accumulated evidence indicated an association between MTHFR C677T polymorphism and MM in Caucasians under a dominant model.

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“…Early studies of DNA methylation in cancer cells correlated baseline or induced gene-specific hypomethylation with gene expression (Christman et al 1977, Liteplo, Frost, and Kerbel 1984, Kelley et al 1988. Numerous other studies have focused on repetitive DNA elements as targets of hypomethylation in the cancer genome (Dante 1988, Costa et al 2006, Ehrlich et al 2006. Hypomethylation of repetitive elements has been associated with chromosomal instability in tumors, perhaps by facilitating aberrant recombination events (Richards et al 2009, Daskalos et al 2009, Nishida et al 2013).…”

Section: Global Hypomethylation In Cancermentioning

confidence: 99%

A decade of DNA methylation profiling in cancer: What have we learned?

Sharma

Kuerbitz

2015

MRAJ

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Abstract-Investigators have studied DNA methylation in tumor cells for nearly 50 years. Differences in gene-specific methylation between cancer cells and their normal counterparts were described more than 30 years ago. From early techniques that measured overall DNA methylation levels to enzyme-associated techniques that interrogated methylation at a single CpG dinucleotide to present day assays that catalogue the methylation of every cytosine in the genome, technical advancement progressively has brought increasing clarity to our understanding of the complex epigenomes of normal and neoplastic cells. Over the past 10 years we have been witness to an explosion of investigation into the epigenetic basis of cancer, and application of the powerful genome-wide DNA methylation profiling techniques to be reviewed have yielded critical insights into the organization of the cancer methylome with its broad regions of hypomethylation and foci of hypermethylation resulting in critical differences in gene expression and chromosomal stability compared to normal cells. These insights, in turn, have prompted novel, testable hypotheses, to be discussed, pertaining to fundamental aspects of cancer biology including the potential stem cell/progenitor cell origins of cancer and the plasticity of gene expression that may underlie tumor heterogeneity and tumor progression. Finally to be discussed is the growing portfolio of epigenetic tools being provided by modern methylome profiling analyses. These biomarker tools are complementing and extending the current genomic tests that are improving cancer diagnosis and that increasingly will facilitate highly individualized cancer treatment in the upcoming decade.

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SATR-1 hypomethylation is a common and early event in breast cancer

Cited by 45 publications

References 28 publications

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

The role of MTHFR gene in multiple myeloma

A decade of DNA methylation profiling in cancer: What have we learned?

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