Saturated Fat Intake and Cardiovascular Disease in Japanese Population

Yamagishi, Kazumasa; Iso, Hiroyasu; Tsugane, Shoichiro

doi:10.5551/jat.28316

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…Observational studies suggest potential antihypertensive and antithrombotic effects of nutrients in dairy foods, including calcium, vitamin D, phosphorus, and potassium, which could lower stroke risk (50)(51)(52)(53)(54)(55). Dairy-specific SFAs also increase HDL cholesterol (1), which could reduce cerebral vascular fragility (45,56), particular in populations with a relatively low consumption of saturated fat. This potential mechanism is supported by 3 Japanese cohorts in middle-aged adults that reported inverse associations between very low intakes of saturated fat and the risk of hemorrhagic stroke or stroke mortality (45)(46)(47), with stronger effects observed in stroke-related lesions in perforating artery regions (45).…”

Section: Discussionmentioning

confidence: 99%

Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Otto

Lemaître

Song

et al. 2018

The American Journal of Clinical Nutrition

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Section: Discussionmentioning

confidence: 99%

Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Otto

Lemaître

Song

et al. 2018

The American Journal of Clinical Nutrition

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“…Although impact of higher saturated fat intake and hypercholesterolemia on CHD among Japanese populations have been reported 43,44) , previous studies on total energy intake have shown either no association or an inverse association with CVD mortality or incidence 8,[11][12][13][14] . The reasons for the observed inconsistency between the previous studies and ours are items enhanced the association between the total energy intake and mortality.…”

Section: Baseline Characteristics By Quintiles Of Total Energy Intakementioning

confidence: 95%

Association of Total Energy Intake with 29-Year Mortality in the Japanese: NIPPON DATA80

Nagai

Miura

Fujiyoshi

et al. 2016

J Atheroscler Thromb

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Aim:In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is different from that in the West. Methods: A total of 7,704 Japanese aged 30 -69 years were followed from 1980 to 2009. Participants were divided into the quintiles of total energy (kcal/day) based on data collected from the National Nutrition Survey. Hazard ratios and 95% confidence intervals (CIs) were derived through the use of Cox proportional hazards models to compare the risk of death across and between the quintiles. Results: There was a significant association between increased energy intake and all-cause mortality risk in only men (P for linear trend 0.008). In cause-specific analysis, compared with the lowest quintile, there was rise in coronary heart disease (CHD) mortality among men (HR; 2.63, 95%CI; 0.95 -7.28, P for linear trend 0.016) and women (HR; 2.91, 95%CI; 1.02 -8.29, P for linear trend 0.032) and cancer mortality among men (HR; 1.50, 95%CI; 0.999 -2.24, P for linear trend 0.038) in the top quintile. Conclusion: We observed significant associations of high energy intake with all-cause and cancer mortality among men and with CHD mortality among men and women. Further studies are needed to confirm the benefits of caloric restriction.

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“…Although SFA consumption increases the risk of stroke in the Western populations, this trend was reversed in Japanese due to a relatively low amount of SFA consumption in Japanese, and the risk tended to be lower with the increasing SFA intake [93,94]. From this situation, consumption of 20 g (<10% E) of SFA daily is recommended to be optimum in Japanese [95]. The specific response patterns in Japan may at least have a connection with a lower risk of T2DM relative to Western countries [4,96].…”

Section: Stroke and Hypertensionmentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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Although most current epidemiologic studies indicate no significant association between consuming one egg daily and blood cholesterol levels and cardiovascular risk, arguments still persist with a positive association. Since the diet is one of the most influential factors for this association, we illustrate characteristic features in Japanese people whose dietary pattern is distinct from that, for example, the US (United States) population. Available epidemiologic studies in healthy Japanese people show no association between consumption of one egg daily and blood cholesterol level, consistent with those observed in the US population. However, when consumption of major nutrients and food sources of cholesterol are compared to the US population, Japanese people may have an extra-reserve against the influence of eggs on cardiovascular risk markers, despite consuming relatively more eggs. Further discussion on the influence of nutrients contained in the egg and dietary pattern, including interaction with gut microbes, is necessary. In addition, special consideration at the personalized level is needed for judgment regarding dietary cholesterol not only for hypercholesterolemic patients but for hyper-responsive healthy persons. Although randomized controlled trials with long-term follow-up are required to evaluate the association between consumption of eggs and human health, available information, at least from the nutritional viewpoint, suggests that egg is a healthy and cost-efficient food worldwide.

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Saturated Fat Intake and Cardiovascular Disease in Japanese Population

Cited by 12 publications

References 23 publications

Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Association of Total Energy Intake with 29-Year Mortality in the Japanese: NIPPON DATA80

Nutritional Viewpoints on Eggs and Cholesterol

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