Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.

Maron, David J.; Fair, Joan M.; Haskell, W. L.

doi:10.1161/01.cir.84.5.2020

Cited by 139 publications

(62 citation statements)

References 46 publications

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“…Due to its higher saturated fat content, regular fat / high fat dairy products were previously believed to increase the risk of type 2 diabetes as a high saturated fat intake is associated with insulin resistance [12,30]. However, cohort studies and a meta-analysis now suggest otherwise, with higher regular fat / high fat dairy consumption being considered mostly neutral or protective for type 2 diabetes [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes

Louie

Flood

Rangan

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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Mitchell, P. 2013, 'Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes', Nutrition, Metabolism and Cardiovascular Diseases, vol. 23,no. 9, Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes AbstractBackground and aims Limited evidence suggests habitual dairy consumption to be protective against metabolic syndrome (MetSyn) and type 2 diabetes among older adults. We assessed the association of baseline consumption of dairy products with the incidence of MetSyn and type 2 diabetes among a cohort of Australian adults aged 49 years and over. Methods and results A validated 145-item semi-quantitative food frequency questionnaire was used to assess food and nutrient intake at baseline. Ten-year incidence of MetSyn and type 2 diabetes were obtained from 1807 and 1824 subjects respectively. Odds ratios (OR) were calculated by discrete time logistic regression modelling. Compared with subjects in the lowest intake quartile of regular fat dairy products, those in the highest quartile had a 59% lower risk of MetSyn (multivariate adjusted OR: 0.41; 95% CI: 0.23-0.71; ptrend = 0.004), after adjustment for risk factors. Among obese subjects, an association between a high intake of regular fat dairy foods and reduced risk of type 2 diabetes was also found (age and sex adjusted OR 0.37; 95% CI: 0.16-0.88; ptrend = 0.030), but the association did not persist after adjustment for additional confounders. There was no association between total dairy consumption and risk of MetSyn or type 2 diabetes. Conclusions We found an inverse association between regular fat dairy consumption and risk of MetSyn among Australian older adults. Further studies are warranted to examine the association between weight status, dairy consumption and risk of type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes

Louie

Flood

Rangan

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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“…A role in the onset of type 2 diabetes might be played by saturated and trans-fatty acids present in meat. Several studies suggested a detrimental effect of saturated fat (animal origin foods as main source) [35][36][37][38] Fig. 1 Country-specific and overall HR for type 2 diabetes associated with 50 g increments of consumption of total meat (a), red meat (b), processed meat (c), poultry (d), offals (e) and meat iron intake (1 mg increments) (f) overall.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study

et al. 2012

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Aims/hypothesis A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

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“…Also, circulating fatty acids, both observationally and experimentally, seem closely involved in the pathogenesis of type 2 diabetes [31,33]. Depending on chain length, fatty acids also stimulate insulin secretion [34,35], which may further aggravate hepatic insulin resistance [36]. The fall in NEFA after glucose challenge between the sites (Fig.…”

Section: Discussionmentioning

confidence: 99%

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

et al. 2005

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Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p<0.001). Conversely, fasting insulin, IGFBP-3 and IGF-I were all higher in UK Gujaratis (mean IGF-I 145.9 [138.1-153.6]ng/ml in UK Gujaratis and 100.9 [94.6-107.3] ng/ml in Navsari Gujaratis; F=76.6, p<0.001). These differences were still apparent when adjustment was made for BMI by location for IGF-I (F=57.4, p<0.001) and IGFBP-3 (F=5.7, p=0.02), but were no longer apparent for IGFBP-1 and insulin. At the population level, the decrease in IGFBP-1 for a given increase in insulin was significantly smaller in UK Gujaratis, suggesting greater hepatic insulin resistance in this group. Conclusions/interpretation: Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP-1, IGF-I and related metabolic variables. This may have long-term implications for the development of worsening glucose tolerance and cardiovascular disease.

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Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.

Cited by 139 publications

References 46 publications

Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes

Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes

Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

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