Saturated Fractions of 2nand 3nFactorial Designs

Rechtschaffner, R. L.

doi:10.1080/00401706.1967.10490505

Cited by 22 publications

(3 citation statements)

References 10 publications

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“…For two levels factors, Rechtschaffner [19] described fractions of 2 n factorial designs with interesting properties. These designs are indeed saturated: the number of runs is limited to 16 for 5 factors.…”

Section: Empirical Modelmentioning

confidence: 99%

Relevance of the choice of spark plasma sintering parameters in obtaining a suitable microstructure for iodine-bearing apatite designed for the conditioning of I-129

Campayo

Gallet

Perret

et al. 2015

Journal of Nuclear Materials

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Section: Empirical Modelmentioning

confidence: 99%

Relevance of the choice of spark plasma sintering parameters in obtaining a suitable microstructure for iodine-bearing apatite designed for the conditioning of I-129

Campayo

Gallet

Perret

et al. 2015

Journal of Nuclear Materials

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“…In order to estimate the coefficients β, we performed a Rechtschaffner design [44]. It is a subset of the experiments from the full factorial design with 22 experiments (mixtures) for each genotoxicity assay.…”

Section: Experimental Factors and Domain Of Interestmentioning

confidence: 99%

In Vitro Genotoxicity Evaluation of PAHs in Mixtures Using Experimental Design

Castel

Tassistro

Claeys‐Bruno

et al. 2023

Toxics

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Settled dusts are sinks for environmental pollutants, including Polycyclic Aromatic Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic. To assess their toxicity in mixtures, Toxic Equivalent Factors (TEFs) are routinely used and based on the hypothesis of additive effects, although PAH interactions may occur and remain an open issue. This study investigated genotoxic binary interaction effects for six PAHs in mixtures using two in vitro assays and estimated Genotoxic Equivalent Factors (GEFs) to roughly predict the genotoxicity of PAH in mixtures. The Design of the Experiment approach was used with the micronucleus assay for cytostasis and micronuclei frequency and the alkaline comet assay for DNA damage. GEFs were determined for each PAH independently and in a mixture. For the cytostasis endpoint, no PAHs interaction was noted. BbF and BaP had a synergistic effect on DNA damage. All the PAH interacted between them regarding chromosomal damage. Although the calculated GEFs were similar to the TEFs, the latter may underestimate the genotoxic potential of a PAH mixture. GEFs calculated for PAH alone were lower than GEFs for PAHs in mixtures; thus, mixtures induce greater DNA/chromosomal damage than expected. This research helps to advance the challenging issue of contaminant mixtures’ effects on human health.

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“…The construction and analysis of 2n3"' factorial designs is discussed in (111), (356), and (357). Saturated fractions of 21* and 3" designs are considered in (444). More general k factoral designs are dealt with in (438).…”

Section: Measurement Processmentioning

confidence: 99%