Sauchinone prevents IL‐1β‐induced inflammatory response in human chondrocytes

Gao, Yanjun; Zhao, Hongyu; Li, Yang

doi:10.1002/jbt.22033

Cited by 13 publications

(7 citation statements)

References 26 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the expression of COX-2 in inflammatory response is soared to increase the pathological synthesis of prostaglandin E2, thus intensifying the development of inflammation and joint injury (12). Moreover, IL-1β can induce the high expression of COX-2 in endothelial cells (13).…”

Section: Discussionmentioning

confidence: 99%

Expressions and clinical significance of interleukin-1β and cyclooxygenase-2 in serum and synovia of patients with gouty arthritis

Chen

Xiang

Zou

et al. 2022

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

Background: To explore the expressions and clinical significance of interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) in serum and synovia of patients with gouty arthritis (GA). Materials and Methods: A total of 110 GA patients hospitalized from January 2016 to September 2019 were selected as observation group, with 55 at remission stage (observation group I) and 55 at acute attack stage (observation group II). Another 55 healthy volunteers were selected as control group. The correlations of IL-1β and COX-2 with uric acid (UA) were explored by Spearman’s analysis. IL-1β and COX-2 expression levels were compared at different time points after treatment. Results: IL-1β, COX-2 and UA levels of patients were significantly higher in observation group I and II than those in the control group, and higher in the observation group II than those in observation group I. IL-1β and COX-2 were positively correlated with UA (P<0.05). ROC curve analysis showed that the optimal cut-off values of IL-1β and COX-2 for predicting GA were 18.23 and 9.12 pg/mL, and AUC values were 0.702 and 0.714 (P<0.001), respectively. On admission and after treatment for 3, 7, and 10 days, IL-1β and COX-2 levels of observation group II significantly exceeded those of observation group I (P<0.05). Compared with the efficacy group, after treatment for 14 days, IL-1β and COX-2 levels in serum and synovia significantly increased in the non-efficacy group (P<0.05). Conclusion: IL-1β and COX-2 levels in serum and synovia of GA patients are evidently higher than those in the control group, which rise with the aggravation of disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Expressions and clinical significance of interleukin-1β and cyclooxygenase-2 in serum and synovia of patients with gouty arthritis

Chen

Xiang

Zou

et al. 2022

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

show abstract

“…A solution of 5-allyloxy-4-methoxy-1,3-benzodioxole 16 in acetone (1.5 M) was loaded in a PEEK injection loop (2 mL) connected to a stream of acetone pumped at a flow rate of 2 mL/min as depicted in Scheme 2. The [3,3]-Claisen rearrangement occurred in a stainless steel reactor coil (5 mL, 0.75 mm id) heated at 250 °C. The line was constantly pressurized at 70 bar with an electronic back pressure regulator (BPR) to prevent the vaporization of acetone.…”

Section: ■ Conclusionmentioning

confidence: 99%

“…1 The most representative members of benzoxanthenone-based natural products include carpanone 1, polemannone A-C 2-4 and sauchinone 5 and feature a highly oxygenated polycyclic structure with five contiguous stereogenic centers ( Figure 1). They have been identified as biologically relevant targets with anti-inflammatory, [2][3] hepatoprotective, [4][5] and antitumor properties. 6 Synthetic analogues have also been reported to be potent inhibitors of exocytosis and might be useful for the study of vesicular traffic.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The most representative members of benzoxanthenone-based natural products include carpanone 1 , polemannone A–C 2 – 4 , and sauchinone 5 and feature a highly oxygenated polycyclic structure with five contiguous stereogenic centers (Figure ). They have been identified as biologically relevant targets with anti-inflammatory, , hepatoprotective, , and antitumor properties . Synthetic analogues have also been reported to be potent inhibitors of exocytosis and might be useful for the study of vesicular traffic. , Therefore, the significant complexity of the benzoxanthenone skeleton, associated with the potential of these structures to interfere with several biological mechanisms, makes these structures appealing targets for synthetic chemists.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis

et al. 2019

View full text Add to dashboard Cite

Naturally occurring benzoxanthenones which belongs to the vast family of lignans, are promising biologically relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this manuscript, we disclose a powerful automated flow-based strategy for identifying and optimizing a cobalt-catalyzed oxidizing system for the bio-inspired dimerization of 2-propenyl phenols. We designed a reconfigurable flow reactor associating on-line monitoring and process-control instrumentation. Our machine was first configured as an automated screening platform to evaluate a matrix of 4 catalysts (plus the blank) and 5 oxidant (plus the blank) at two different temperatures, resulting in an array of 50 reactions. The automated screening was conducted on micromole scale at a rate of one fully characterized reaction every 26 minutes. After having identified the most promising cobaltcatalyzed oxidizing system, the automated screening platform was straightforwardly reconfigured to an autonomous self-optimizing flow reactor by implementation of an optimization algorithm in the closed-loop system. The optimization campaign allowed the determination of very effective experimental conditions in a limited number of experiments which allowed to prepare natural products carpanone and polemannone B as well as synthetic analogues.

show abstract

“…Sauchinone suppressed the gene expression of inflammatory cytokines such as interleukin (IL)-5 and IL-13, consequently suppressing allergic airway inflammation in a murine model of allergic asthma [ 4 ]. In addition, sauchinone has been reported to inhibit the inflammatory response in acute lung injury [ 5 ], osteoarthritis [ 6 , 7 ], and colitis [ 8 , 9 ]. The anti-inflammatory effect of sauchinone is attributed to its anti-oxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway

et al. 2021

View full text Add to dashboard Cite

Sauchinone, a lignan isolated from Saururus chinenesis, is known to exhibit anti-inflammatory and anti-oxidant effects. Recently, sauchinone has been reported to inhibit the growth of various cancer cells, but its effects on breast cancer cells remain poorly understood. In this study, we investigated the effects of sauchinone on the growth of breast cancer cells along with the underlying molecular mechanisms. Our results show that sauchinone treatment markedly inhibited the proliferation, migration, and invasion of breast cancer cells. Sauchinone reduced the phosphorylation of Akt, ERK, and CREB increased by transforming growth factor-β. In particular, sauchinone treatment suppressed the expression of matrix metalloproteinase-13 (MMP13) by regulating the Akt-CREB signaling pathway. Sauchinone was less effective in inhibiting cell migration in Mmp13-knockdown cells than in control cells, suggesting that MMP13 may be a novel target for sauchinone. Our study suggests that sauchinone inhibits the growth of breast cancer cells by attenuating the Akt-CREB-MMP13 pathway. In addition, the targeted inhibition of MMP13 by sauchinone represents a promising approach for the treatment of breast cancer.

show abstract

Sauchinone prevents IL‐1β‐induced inflammatory response in human chondrocytes

Cited by 13 publications

References 26 publications

Expressions and clinical significance of interleukin-1β and cyclooxygenase-2 in serum and synovia of patients with gouty arthritis

Expressions and clinical significance of interleukin-1β and cyclooxygenase-2 in serum and synovia of patients with gouty arthritis

Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis

Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway

Contact Info

Product

Resources

About