BackgroundSaudi Arabia has 13 administrative areas, all of which have been seriously affected by the COVID-19 epidemic regardless of their features. Being the largest and a prominent Arab country, epidemic intensity and dynamics have importance, especially in the era of Vision 2030 where infrastructure development and growth to enhance quality of life has of prime focus.AimsThis analysis aims to trace the differentials in COVID-19 infections, recoveries, and deaths across the country depending upon various demographic and developmental dimensions and interactions.Data and methodsThis analysis used Saudi Arabia Ministry of Health data from March 15th, 2020 to August 31st, 2022, by classifying administrative areas and locations to build a generalized linear model (3 × 3): three types of administrative areas (major, middle-sized, and others) and localities (major, medium-sized, and others). Apart from two-way ANOVA, an one-way ANOVA also carried out in addition to calculating mean values of infections, recoveries, and deaths.ResultsA total of 205 localities were affected with varying severity, which are based on local demographics. Both the administrative areas and localities had a significant number of cases of infections, recoveries, and mortality, which are influenced by relationships and interactions, leading to differential mean values and proportional distributions across various types of administrative areas and localities.ConclusionThere is dynamism that major administrative areas have lesser threats from the epidemics whereas medium-sized ones have serious threats. Moreover, an interaction of administrative areas and localities explains the dynamics of epidemic spread under varying levels of infrastructure preparedness. Thus, this study presents lessons learned to inform policies, programs, and development plans, especially for regional, urban, and infrastructure areas, considering grassroots level issues and diversity.