Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats

Harakeh, Steve; Saber, Saber H.; Akefe, Isaac Oluwatobi; Shaker, Soad; Hussain, Muddassar; Almasaudi, Arwa S.; Saleh, Shimaa M.M.; Almasaudi, Saad B.

doi:10.1016/j.sjbs.2022.01.031

Cited by 16 publications

(10 citation statements)

References 27 publications

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“…Pretreatment with FAM or C. aspersum mucin, at a high dose, normalized gastric MDA contents. Our results were in harmony with [ 55 ] who stated that IND intoxication resulted in a significant increase in the level of MDA, and a significant decrease in the activities of GSH, and catalase. Yet, pretreatment with C. aspersum mucin at a low dose significantly reduced (p < 0.05) the level of MDA by 26.52% compared with the ulcerated controls.…”

Section: Resultssupporting

confidence: 92%

Cornu aspersum mucin attenuates indomethacin-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Salem¹,

Elzallat²,

Mohammed³

et al. 2023

Heliyon

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Section: Resultssupporting

confidence: 92%

Cornu aspersum mucin attenuates indomethacin-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Salem¹,

Elzallat²,

Mohammed³

et al. 2023

Heliyon

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“…germinated fenugreek seed extractand standard (ranitidine) drug-treated group-IV, V, and VI respectively. MDA is the byproduct of lipid peroxidation and is utilized as a pointer to quantify the rate of lipid peroxidation [24]. In our findings, TBARS level was significantly high (p<0.01) in ulcer control and the self-healing group than normal control group but declined (p<0.01) TBARS level was observed in groups who are post-treated by the fixed doses of ethanolic extract and ranitidine treated rats as compared to the self-healing group.…”

Section: Discussionsupporting

confidence: 48%

Evaluation of anti-ulcer potential of Germinated Trigonella foenum graecum ethanolic extract in SD rats

Idris¹,

Mishra²,

Khushtar³

et al. 2022

YMER

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The current experiment was performed to examine the therapeutic action of extract against gastric ulcers in SD rats. Though this experiment explains that the germinated fenugreek seed extract showed significant improvement in gastric mucosa conditions after Indomethacininduced gastric lesions (p<0.01). Further marked improvement in antioxidant enzymes such as SOD, and Catalase was observed (P<0.01), if compared to self-healing and untreated ulcer induced groups. Histopathology reports also explain that germinated fenugreek seed extract improved the epithelial layer in treated groups compared to untreated ulcer-induced groups. Keywords: Trigonella foenum graeucum, germination, pharmacological action, gastroprotective activity

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“…Others have reported that honey ameliorates the influence of hemorrhage and food restriction on renal and hepatic functions as well as hematological and biochemical variables. [33][34][35] The in-vitro cytoprotective effect of honey against chromosomal breakage in patients with Fanconi anemia also has been reported; however, further confirmation in vivo is needed. 36 Honey is unique in its ability to augment the process of detoxification.…”

Section: Discussionmentioning

confidence: 96%

Medical-grade Spore-free Natural Honey is an Effective Choleretic in Neonatal Cholestasis: A Pilot Single-center Trial

Kotb¹,

Satar²,

Badr³

et al. 2023

Gene Expr

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Background and objectives: Liver damage in cholestasis is multifactorial, yet bile acid-mediated hepatotoxicity is pivotal. Honey consumption has many physiological effects; it influences detoxification process (phase I, II and III), has antioxidant, anti-inflammatory, immune-stimulant, anti-ulcer, wound/burn healing effects and others. The bile acid ursodeoxycholic acid (UDCA) is currently used off-label to treat neonatal cholestasis. This study aimed to assess the effectiveness of spore-free natural honey to treat neonatal nonobstructive cholestasis.Methods: Thirty infants with cholestasis received spore-free natural honey. Their progression was compared to a control group with cholestasis (28 infants) and a historical group (31 infants) on UDCA. Results:The mean ± standard deviation (SD) follow-up duration was 29.68 ± 18.68 months. At presentation, the total bilirubin concentrations were 9.5 ± 5.9 mg/dL, 10.9 ± 7 mg/dL and 14 ± 9 mg/dL in the honey, control and UDCA groups, respectively (p = 0.064), and their direct bilirubin concentrations were 6 ± 4 mg/dL, 6.7 ± 4 mg/dL and 8.4 ± 6.9 mg/dL, respectively (p = 0.169). The final total bilirubin concentrations were 1.2 ± 1.7 mg/dL, 4.6 ± 8.2 mg/dL and 7.3 ± 8.9 mg/dL, (p = 0.006), and their final direct bilirubin concentrations were 0.8 ± 1 mg/dL, 2.77 ± 5.2 mg/dL and 5.1 ± 7.2 mg/dL (p = 0.008), with cure achievement in 25, 16 and 16 (p = 0.023), improvement in 3, 5 and 3 (p = 0.565), failure in 2, 3 and 10 (p = 0.016), and death in 0, 4 and 2, respectively (p = 0.095). None suffered from botulism or flaccid paralysis.Conclusions: Spore-free honey is effective in clearing cholestasis in neonates and infants. UDCA use in cholestasis in pediatric age should be abandoned as it is less effective and is associated with a worse outcome.

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Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats

Cited by 16 publications

References 27 publications

Cornu aspersum mucin attenuates indomethacin-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Cornu aspersum mucin attenuates indomethacin-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Evaluation of anti-ulcer potential of Germinated Trigonella foenum graecum ethanolic extract in SD rats

Medical-grade Spore-free Natural Honey is an Effective Choleretic in Neonatal Cholestasis: A Pilot Single-center Trial

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