Saving-effect of stimulating pulses at low-frequency amygdaloid kindling in cats

Minabe, Yoshio; Tanii, Yasuyuki; Kadono, Youichi; Tsutsumi, Manabu; Nakamura, Ichiro

doi:10.1016/0006-8993(86)91568-4

Cited by 8 publications

(1 citation statement)

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“…Kindled seizures could be induced with low-frequency electrical stimulations in rats4 and in cats. 13 This "low-frequency kindling" was used as a new experimental model of epilepsy in assessing antiepileptic+ l5 and psychotropic drugs. 16 In the low-frequency kindling, the indicator of the seizure gen-erating threshold is the number of stimulating pulses required for the induction of epileptic afterdischarge, and we could measure the seizure generating threshold and severity of induced seizures quantitatively and simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Acute Effect of TRH, Fhmarizine, Lithium and Zotepine on Amygdaloid Kindled Seizures Induced with Low‐Frequency Stimulation

Minabe

Tanii

Tsunoda

et al. 1987

Psychiatry Clin Neurosci

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We assessed the acute effects of various drugs on amygdaloid kindled seizures induced with low‐frequency stimulations. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse‐number threshold; PNT) as an indicator of the seizure generating threshold and the duration of induced seizures (AD duration; ADD) as an indicator of the seizures. TRH increased the PNT without affecting the ADD at a high dose (1.2 mg/kg). Flunarizine decreased the PNT and ADD simultaneously at a high dose (50 mg/kg). Lithium increased the PNT without affecting the ADD at two doses (100 mg/kg, 200 mg/kg). Zotepine decreased the PNT without affecting the ADD at two doses (8 mg/kg, 16 mg/kg). We propose that the technique of low‐frequency kindling is a useful experimental model in assessing the effects of antipsychotic or antiepileptic drugs on the excitability of the limbic regions.

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Section: Introductionmentioning

confidence: 99%