This work demonstrates a low-power, light-weight, and cost-efficient vacuum pressure sensor and air leak detector based on 2 mm x 2 mm Cu/HfO2/p + -Si memristor device. The operating principle of the proposed sensor relies on monitoring the off-state resistance (Roff) of the device, wherein the experimental results show that the Roff value is inversely proportional to the vacuum pressure. The fabricated sensors demonstrated a sensitivity of 493 Torr -1 and power consumption as low as ~ 8 nW, when tested in a wide range of sub-atmospheric pressure (4.9x10 -5 -760) Torr, making them highly suitable for low-power applications. Furthermore, it is shown that the sensor can be integrated with a microcontroller-based circuitry to serve as a standalone sensing system.