ABSTRACT… Objectives:To determine the effects of Botulinum toxin A (BoNTA) with task specific training on hand function and quality of life in patients with post stroke focal dystonia of hand. Study Design: Randomized Controlled Trial. Place and Duration of Study: This study was conducted in Holy family hospital, The Neurocounsel and Chambeli Rehabilitation center from October 2015 to September 2016. Methodology: Both male and female patients suffering from stroke for at least 6 months with focal hand dystonia were included in this randomized controlled trial. 46 patients were recruited in the study through non probability purposive sampling and then were allocated to control (n=23) and experimental group (n=23) by random number list generated for 46 patients using SPSS software. Control group was provided with only task specific training while experimental group was provided with an injection of Botulinum Toxin A in addition to task-specific training. Data was collected from both groups at baseline and then after 8 weeks by using Action Research Arm Test (ARAT), Stroke specific quality of life (SS-QOL) and Arm dystonia disability scale (ADDS). Results: Although both groups showed significant improvements after training(P value <0.001) in both ARAT scale and SS-QOL but as shown by the difference of means of the groups, experimental group has shown more improvement than control group at the end of 8 weeks of intervention with P value<0.05. ADDS has also shown better results in reducing disability in experimental group as compared to control group. Conclusion: Botulinum toxin A prior to start of task specific training significantly improves outcome in post stroke focal hand dystonia patients than task specific training alone.
Key Words:Focal Dystonia, Quality of Life, Task Specific Training, Botulinum Toxin A, SS-QOL.